126705-22-4

Basic information

• Product Name: FMOC-ACPC-OH
• Synonyms: FMOC-ACPC-OH;FMOC-AC3C-OH;FMOC-1-AMINO-1-CYCLOPROPANE CARBOXYLIC ACID;FMOC-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID;FMOC-(1)NHCPROPN-OH;FMOC-(1)NH-DELTA-OH;FMOC-1, 1-ACCP;1-(FMOC-AMINO)-CYCLOPROPANECARBOXYLIC ACID
• CAS NO: 126705-22-4
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.34
• Product Categories: FMOC;Amino Acid Derivatives;Amino Acids;Peptide;Alicyclic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives;Isoquinolines ,Quinolines ,Quinaldines
• Mol File: 126705-22-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 225-226
• Boiling Point: 566.9 °C at 760 mmHg
• Flash Point: 296.7 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 1.09E-13mmHg at 25°C
• Refractive Index: 1.671
• Storage Temp.: 2-8°C
• PKA: 3.97±0.20(Predicted)
• BRN: 9348574
• CAS DataBase Reference: FMOC-ACPC-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-ACPC-OH(126705-22-4)
• EPA Substance Registry System: FMOC-ACPC-OH(126705-22-4)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 126705-22-4(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

InChI:InChI=1/C19H17NO4/c21-17(22)19(9-10-19)20-18(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,20,23)(H,21,22)

Upstream product

• 22059-21-8 aminocyclopropane-1-carboxylic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 1446358-61-7 C₂₁H₁₉FN₈O₂ 

Relevant articles and documents

Convenient synthesis and isolation of 1-aminocyclopropane-1-carboxylic acid (ACC) and N-protected ACC derivatives

A convenient route to 1-aminocyclopropane-1-carboxylic acid (1, ACC) and N-protected derivatives was developed. This route utilizes a bisalkylation of an O-benzyl glycine derived imine followed by global deprotection via hydrogenation. Direct isolation of ACC from a non-aqueous stream or efficient conversion to N-protected derivatives in a single flask is described.

Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2

Nuclear hormone receptor (NR) signaling, currently a therapeutic target in multiple diseases, involves an ordered series of protein interactions to regulate transcription in response to changing hormone levels. Later steps in the process of ligand-dependent signaling are driven by a highly conserved interaction between the NRs and the steroid receptor coactivators (SRCs) that is effected by a conserved interaction motif (L1XXL2L3), known as an NR box. Using computational design and combinatorial chemistry, we have produced novel ∞-helical proteomimetics of the second NR box of SRC2 that exploit structural differences between human estrogen receptor ∞ (hER∞), human estrogen receptor β (hERβ), and human thyroid hormone receptor β (hTRβ). The resulting library sequentially replaced each leucine with non-natural side chains. Screening this library using a quantitative competition assay revealed compounds that selectively inhibit the interaction of SRC2-2 with each individual NR in preference to its interaction with the other NR. This approach generated highly selective compounds from one that had no specificity for a particular family member. These compounds represent the first family-member-selective competitive inhibitors of the protein interactions of transcription factors. Copyright