1267597-50-1

Basic information

• Product Name: (R)-4-isopropyl-3-((S)-2-methylpent-4-enoyl)-5,5-diphenyloxazolidin-2-one
• Synonyms: (R)-4-isopropyl-3-((S)-2-methylpent-4-enoyl)-5,5-diphenyloxazolidin-2-one
• CAS NO: 1267597-50-1
• Molecular Weight: 377.483
• Mol File: 1267597-50-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-4-isopropyl-3-((S)-2-methylpent-4-enoyl)-5,5-diphenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-isopropyl-3-((S)-2-methylpent-4-enoyl)-5,5-diphenyloxazolidin-2-one(1267597-50-1)
• EPA Substance Registry System: (R)-4-isopropyl-3-((S)-2-methylpent-4-enoyl)-5,5-diphenyloxazolidin-2-one(1267597-50-1)

Safety Data

• Hazardous Substances Data: 1267597-50-1(Hazardous Substances Data)

Upstream product

• 556-56-9 allyl iodid 
• 223906-53-4 (4R)-N-Propionyl-5,5-diphenyl-4-isopropyloxazolidin-2-one 
• 191090-32-1 (R)-4-(1-methylethyl)-5,5-diphenyl-1,3-oxazolidin-2-one 
• 106-95-6 allyl bromide 

Downstream Products

• 887706-39-0 (S)-5-(benzyloxy)-4-methylpentan-1-ol 
• 1267597-34-1 (2S,5S,9S)-1-(benzyloxy)-9-(tert-butyldimethylsilyloxy)-2-methyldec-6-yn-5-ol 
• 1267597-35-2 [(2S,6S,9S)-10-(benzyloxy)-6-(methoxymethoxy)-9-methyldec-4-yn-2-yloxy](tert-butyl)dimethylsilane 
• 1267597-37-4 5-[(2S,5R,9S)-9-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)-2-methyldecylthio]-1-phenyl-1H-tetrazole 
• 1267597-38-5 5-((2S,5R,9S)-9-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)-2-methyldecylsulfonyl)-1-phenyl-1H-tetrazole 
• 1267597-39-6 2-bromo-1-[(3'S,6'R,10'S,E)-10-tert-butyldimethylsilyloxy-6-(methoxymethoxy)-3-methylundec-1-enyl]-3,5-dimethoxybenzene 
• 1267597-40-9 methyl 2-[(3S,6R,10S,E)-10-(tert-butyldimethylsilyloxy)-6-(methoxymethoxy)-3-methylundec-1-enyl]-4,6-dimethoxybenzoate 
• 1267597-41-0 methyl 2-[(3S,6R,10S,E)-10-hydroxy-6-(methoxymethoxy)-3-methylundec-1-enyl]-4,6-dimethoxybenzoate 
• 1267597-42-1 2-[(3S,6R,10S,E)-10-hydroxy-6-(methoxymethoxy)-3-methylundec-1-enyl]-4,6-dimethoxybenzoic acid 
• 180692-68-6 (S)-5-(phenylmethoxy)-4-methylpentanal 
• 391208-05-2 (S)-1-((2-methylpent-4-enyloxy)methyl)benzene 
• 1357569-97-1 C₂₄H₃₂F₃N₃O₄ 
• 152441-67-3 benzyl (S)-2-methyl-4-oxabutanoate 
• 147649-95-4 (S)-2-Methyl-4-pentenoic acid phenylmethyl ester 

Relevant articles and documents

Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones

Identifying the targets of bioactive small molecules is a challenging endeavor for which no general solution currently exists. Classical affinity purification experiments suffer from the need to functionalise a bioactive compound and link it to a solid support, which may interfere with target binding. A modern mass spectrometry-based proteomics technique that has partially circumvented this problem is thermal proteome profiling (TPP), which determines the effect of an unmodified small molecule on the thermal stability of the whole proteome simultaneously. Here, we use TPP to identify the mode-of-action of a newly-discovered autophagy inhibitor based on oxazolidinones often employed as chiral auxiliaries. Surprisingly, a significant portion of all ribosomal proteins were found to be destabilized by the inhibitor, highlighting the utility of this technology for determining a challenging mode-of-action.

Probing the influence of an allylic methyl group in zearalenone analogues on binding to Hsp90

By the replacement of an acetate with propionate by means of organic synthesis, a range of zearalenone analogues were prepared that feature an allylic methyl group. For the synthesis of the aliphatic region of the analogues, we used an asymmetric alkylati