126764-32-7

Basic information

• Product Name: 1H-Pyrazole-4-carboxaldehyde, 1,3-dimethyl-5-(2,2,2-trifluoroethoxy)-
• CAS NO: 126764-32-7
• Molecular Formula: C8H9F3N2O2
• Molecular Weight: 222.167
• Mol File: 126764-32-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxaldehyde, 1,3-dimethyl-5-(2,2,2-trifluoroethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxaldehyde, 1,3-dimethyl-5-(2,2,2-trifluoroethoxy)-(126764-32-7)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxaldehyde, 1,3-dimethyl-5-(2,2,2-trifluoroethoxy)-(126764-32-7)

Safety Data

• Hazardous Substances Data: 126764-32-7(Hazardous Substances Data)

Usage

Derivative of pyrazole-4-carboxaldehyde

yes, with two methyl groups and a trifluoroethoxy group added

Common uses

pharmaceutical and agrochemical industries as a building block for the synthesis of biologically active compounds

Value

intermediate for the production of new drugs and pesticides, used in research and development of new chemical entities

Potential applications

materials science and organic synthesis.

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 27006-76-4 5-chloro-4-formyl-1,3-dimethylpyrazole 

Relevant articles and documents

Stereoselective synthesis and antifungal activities of (E)-α- (methoxyimino)benzeneacetate derivatives containing 1,3,5-substituted pyrazole ring

Thirteen novel (E)-α-(methoxyimino)benzeneacetate derivatives, the analogues of strobilurins, which contain two pharmacophoric substructures of the methyl (E)-methoxyiminoacetate moiety and 1,3,5-substituted pyrazole ring, were stereoselectively synthesized. It was found that the coupling reaction could give stereoselectively (E:Z ca. 14:1) the key intermediate material (E)-methyl 2-(hydroxyimino)-2-o-tolyl acetate (2). An X-ray crystallographic structure determination was carried out in a representative product. The preliminary bioassays indicated that all of the compounds 1 showed potent fungicidal activity against Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Physalospora piricola, and Bipolaris mayclis.