1267808-41-2

Basic information

• Product Name: (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester
• Synonyms: (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester
• CAS NO: 1267808-41-2
• Molecular Weight: 664.84
• Mol File: 1267808-41-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester(1267808-41-2)
• EPA Substance Registry System: (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester(1267808-41-2)

Safety Data

• Hazardous Substances Data: 1267808-41-2(Hazardous Substances Data)

Upstream product

• 2483-46-7 Boc-Lys(Boc)-OH 
• 55592-82-0 (S)-(5-tert-butoxycarbonylamino-5-carbamoyl-pentyl)carbamic acid tert-butyl ester 
• 114594-04-6 (S)-benzyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoate 
• 109-89-7 diethylamine 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 159541-28-3 (S)-6-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid benzyl ester 
• 30189-36-7 N,N'-di-t-butyloxycarbonyl-(S)-lysine N-hydroxysuccinimide ester 

Relevant articles and documents

PROCESS FOR GALNAC OLIGONUCLEOTIDE CONJUGATES

The invention comprises a process for the preparation of therapeutically valuable GalNAc cluster oligonucleotide conjugates. The process comprises the coupling of an alkali metal salt, earth alkali metal salt or a tetraalkylammonium salt of an oligonucleotide with a GalNAc cluster compound or with a salt thereof and a subsequent purification.

GalNAc CLUSTER PHOSPHORAMIDITE

The invention comprises Gal NAc phosphoramidite derivatives of the formula (I), wherein R1 is a hydroxy protecting group, n is an integer from 0 to 10 and m is an integer from 0 to 20 and its corresponding enantiomers and/ or optical isomers thereof. The invention further comprises a process for the preparation of the Gal NAc phosphoramidite derivatives of the formula (I) and its use in the preparation of therapeutically valuable GalNAc-cluster oligonucleotide conjugates.

Galactose cluster-pharmacokinetic modulator targeting moiety for siRNA

The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinet