1268467-88-4Relevant articles and documents
Tetrahydroquinoline derivatives as opioid receptor antagonists
Zhang, Cunyu,Westaway, Susan M.,Speake, Jason D.,Bishop, Michael J.,Goetz, Aaron S.,Carballo, Luz Helena,Hu, Mike,Epperly, Andrea H.
scheme or table, p. 670 - 676 (2011/03/18)
Opioid receptors play an important role in both behavioral and homeostatic functions. We herein report tetrahydroquinoline derivatives as opioid receptor antagonists. SAR studies led to the identification of the potent antagonist 2v, endowed with 1.58 nM