126918-35-2

Basic information

• Product Name: (1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol
• Synonyms: (1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol
• CAS NO: 126918-35-2
• Molecular Weight: 200.185
• Mol File: 126918-35-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: (1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol(126918-35-2)
• EPA Substance Registry System: (1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol(126918-35-2)

Safety Data

• Hazardous Substances Data: 126918-35-2(Hazardous Substances Data)

Usage

Description

(1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol is a complex chiral chemical compound characterized by a 1R-ethanol molecule connected to a 2R-2-oxiranyl group, which in turn bears a 2,4-difluorophenyl substituent. The 2R-2-oxiranyl group features a three-membered ring with one oxygen atom, and the 2,4-difluorophenyl substituent is a benzene ring with two fluorine atoms attached. (1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol's chiral nature suggests it may have unique properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
(1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol is used as a chiral building block for the synthesis of pharmaceutical compounds due to its unique structure and the presence of fluorine atoms, which can influence the compound's lipophilicity and metabolic stability.
Used in Organic Synthesis:
(1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol serves as an intermediate in organic synthesis, particularly for the preparation of complex organic molecules that require chiral centers or specific functional groups, such as those found in pharmaceuticals or agrochemicals.
Used in Materials Science:
(1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol may be utilized in the development of new materials with specific properties, such as chiral polymers or materials with tailored electronic or optical characteristics, given its unique molecular structure and the potential for further functionalization.

Upstream product

• 137035-03-1 [(2S,3R)-2-(2,4-Difluoro-phenyl)-3-methyl-oxiranyl]-methanol 
• 5034-06-0 trimethyl sulfoxonium chloride 
• 126918-16-9 (R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one 
• 25596-24-1 trimethyloxosulfonium bromide 
• 1774-47-6 trimethylsulfoxonium iodide 
• 1610930-73-8 (2S,3S)-4-chloro-3-(2,4-difluorophenyl)-3-((trimethylsilyl)-oxy)butan-2-ol 
• 861718-85-6 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde 
• 861718-83-4 (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 832152-01-9 (2R,3R)-1-chloro-2-(2,4-difluorophenyl)butane-2,3-diol 
• 832151-94-7 (2S,3R)-1-chloro-2-(2,4-difluorophenyl)butane-2,3-diol 
• 127001-03-0 (2S)-2',4'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone 
• 126918-33-0 (1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol 
• 126918-14-7 (2S)-2',4'-Difluoro-2-hydroxypropiophenone 

Downstream Products

• 124627-86-7 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole 
• 126917-48-4 (2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 132507-89-2 (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol 
• 135270-14-3 (R)-1-[(R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl methanesulfonate 
• 126918-36-3 [(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl]methanesulfonate 
• 155432-64-7 2-<(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone 

Relevant articles and documents

PROCESS FOR PRODUCING EPOXY ALCOHOL COMPOUND

A compound represented by formula (II): (where Ar represents a phenyl group optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom and a trifluoromethyl group, and R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms) is produced by step A: reacting trimethyl oxosulfonium salt or trimethyl sulfonium salt with a base in a solvent, and removing the resulting solid to obtain a trimethyl oxosulfonium ylide solution or a trimethyl sulfonium ylide solution; and step B: reacting a compound represented by formula (I): and the solution obtained in step A, and the compound represented by formula (II) can be derived to a compound represented by formula (V): that is useful for production of an antifungal agent.

Method of purifying 3-phenyl-3,4-epoxy-2-butanol derivatives by liquid-liquid extraction

An epoxy compound of the formula (1): wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, and Ar represents an optionally substituted aromatic group, can be purified by dissolving a crude product containing the epoxy compo

OPTICALLY ACTIVE HALOHYDRIN DERIVATIVE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE EPOXY ALCOHOL DERIVATIVE FROM THE SAME

The present invention provides an industrially safe, easily operable process for producing an optically active epoxy alcohol derivative useful as an intermediate for pharmaceuticals from inexpensively available materials, and also provides a novel halohydrin derivative serving as an important intermediate for the epoxyalcohol derivative. Furthermore, the present invention provides a process for producing an intermediate for a triazole antifungal agent by allowing a halohydrin to react with a triazole sulfonamide, the process including a small number of steps. A process for producing an optically active epoxy alcohol derivative includes allowing an optically active α-substituted propionate derivative to react with a haloacetic acid derivative in the presence of a base to prepare an optically active haloketone derivative, allowing the resulting haloketone derivative to react with an aryl metal compound to stereoselectively prepare a halohydrin derivative, eliminating a substituent for the hydroxy group of the halohydrin derivative, and performing epoxidation with a base. Furthermore, a process for producing an intermediate for a triazole antifungal agent includes allowing a halohydrin derivative to react with a triazole sulfonamide, the process including a small number of steps.