127027-58-1

Basic information

• Product Name: Benzaldehyde, 3-methoxy-5-nitro-4-(phenylmethoxy)-
• CAS NO: 127027-58-1
• Molecular Formula: C15H13NO5
• Molecular Weight: 287.272
• Mol File: 127027-58-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 3-methoxy-5-nitro-4-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 3-methoxy-5-nitro-4-(phenylmethoxy)-(127027-58-1)
• EPA Substance Registry System: Benzaldehyde, 3-methoxy-5-nitro-4-(phenylmethoxy)-(127027-58-1)

Safety Data

• Hazardous Substances Data: 127027-58-1(Hazardous Substances Data)

Upstream product

• 6635-20-7 isonitrovanillin 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 127028-01-7 N-<2-(Benzyloxy)-3-methoxy-5-formylphenyl>acetohydroxamsaeure 
• 312327-10-9 5-[5-[2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)ethyl]-2-benzyloxy-3-methoxyphenylaminomethylene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 312327-11-0 O-benzyl N-2-(tert-butyldimethylsilyloxy)-2-[8-benzyloxy-7-methoxy-4(1H)-quinolinon-5-yl]ethyl carbamate 
• 312327-12-1 O-benzyl N-2-(tert-butyldimethylsilyloxy)-2-[8-benzyloxy-7-methoxy-1-methyl-4(1H)-quinolinon-5-yl]ethyl carbamate 
• 312327-01-8 2-(tert-butyldimethylsilyloxy)-2-(4-benzyloxy-3-methoxy-5-nitrophenyl)ethanonitrile 
• 188658-40-4 2-(4-Benzyloxy-3-methoxy-5-nitro-phenyl)-[1,3]dioxolane 
• 102357-91-5 7-benzyloxy-6-methoxy-1H-indole-4-carbaldehyde 

Relevant articles and documents

Synthesis of 8-methoxy-1-methyl-1H-benzo[de][1-6]naphthyridin-9-ol (isoaaptamine) and analogues

8-Methoxy-1-methyl-1H-benzo[de][1,6]naphthyridin-9-ol, isoaaptamine, a PKC inhibitor isolated from sponge was synthesized. The synthesis parallels a synthesis of 8,9-dimethoxybenzo[de][1,6]-naphthyridine, aaptamine, but uses a nitromethyl substituent as a precursor of the key 5-(2-aminoethyl)-1H-quinolin-4-one intermediate. The quinolone intermediates were prepared by thermolysis (220-240 °C) of anilinomethylene derivatives of Meldrum's acid. The quinolone intermediates were N-methylated prior to cyclization to the benzo[de][1,6]naphthyridine derivatives. Aaptamine and several analogues of aaptamine and isoaaptamine were prepared including 9-demethylaaptamine, 1-methyl-8-demethylaaptamine, 1-methylaaptamine, and the 8,9-methylenedioxy analogues of aaptamine and 1-methylaaptamine.