127033-87-8

Basic information

• Product Name: (E)-N-(4-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl)phenyl)acetamide
• Synonyms: (E)-N-(4-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl)phenyl)acetamide
• CAS NO: 127033-87-8
• Molecular Weight: 295.338
• Mol File: 127033-87-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-N-(4-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(4-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl)phenyl)acetamide(127033-87-8)
• EPA Substance Registry System: (E)-N-(4-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl)phenyl)acetamide(127033-87-8)

Safety Data

• Hazardous Substances Data: 127033-87-8(Hazardous Substances Data)

Upstream product

• 622-50-4 4-Acetamido-1-iodobenzene 
• 2125-49-7 3-dimethylamino-1-(4-methoxy-phenyl)-propan-1-one; hydrochloride 
• 122-85-0 para-acetamidobenzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

Chalcone-Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering

Human pluripotent stem cells (hPSCs) hold great promise for applications in cell therapy and drug screening in the cardiovascular field. Bone morphogenetic protein 4 (BMP4) is key for early cardiac mesoderm induction in hPSC and subsequent cardiomyocyte derivation. Small-molecular BMP4 mimetics may help to standardize cardiomyocyte derivation from hPSCs. Based on observations that chalcones can stimulate BMP4 signaling pathways, we hypothesized their utility in cardiac mesoderm induction. To test this, we set up a two-tiered screening strategy, (1) for directed differentiation of hPSCs with commercially available chalcones (4’-hydroxychalcone [4’HC] and Isoliquiritigen) and 24 newly synthesized chalcone derivatives, and (2) a functional screen to assess the propensity of the obtained cardiomyocytes to self-organize into contractile engineered human myocardium (EHM). We identified 4’HC, 4-fluoro-4’-methoxychalcone, and 4-fluoro-4’-hydroxychalcone as similarly effective in cardiac mesoderm induction, but only 4’HC as an effective replacement for BMP4 in the derivation of contractile EHM-forming cardiomyocytes.

Chalcones: A new class of antimitotic agents

A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-propen- 1-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa