1271002-87-9

Basic information

• Product Name: C₂₂H₂₅Cl₂NO₂
• Synonyms: C₂₂H₂₅Cl₂NO₂
• CAS NO: 1271002-87-9
• Molecular Weight: 406.352
• Mol File: 1271002-87-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₅Cl₂NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₅Cl₂NO₂(1271002-87-9)
• EPA Substance Registry System: C₂₂H₂₅Cl₂NO₂(1271002-87-9)

Safety Data

• Hazardous Substances Data: 1271002-87-9(Hazardous Substances Data)

Upstream product

• 95-50-1 1,2-dichloro-benzene 
• 79560-19-3 4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one 
• 90-15-3 α-naphthol 
• 1186422-36-5 4(S)-(3,4-dichlorophenyl)-3,4-dihydro-N-methyl-1(2H)-naphthalenimine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 124379-29-9 (4S)-4-(3,4-dichlorophenyl)-1-tetralone 
• 261776-41-4 (4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine 
• 312620-93-2 (S)-N-(4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene)methanamine 

Relevant articles and documents

Asymmetric hydrogenation of N-alkyl and N-aryl ketimines using chiral cationic Ru(diamine) complexes as catalysts: The counteranion and solvent effects, and substrate scope

Asymmetric hydrogenation of N-alkyl and N-aryl ketimines catalyzed by chiral cationic η6-arene-(N-monosulfonylated diamine) Ru(II) complexes has been investigated. Strong counteranion and solvent effects on the enantioselectivity were observed. The ruthenium catalyst bearing non-coordinating BArF- anion was found to be particularly effective for the hydrogenation of acyclic and exocyclic N-alkyl ketimines in the presence of (Boc)2O in dichloromethane or even under solvent-free conditions, providing chiral amines with up to >99% ee and full conversions. Alternatively, the ruthenium catalyst bearing achiral phosphate anion together with corresponding phosphoric acid as the additive was also efficient for the hydrogenation of N-alkyl ketimines in the absence of (Boc)2O with excellent enantioselectivities and full conversions. For N-aryl ketimines lower enantiomeric excesses were observed by using the ruthenium catalyst bearing BArF- anion. This catalytic protocol thus provides a facile and practical access to optically active amines and has been successfully employed in the gram-scale synthesis of enantiomerically pure (+)-sertraline.