127105-12-8

Basic information

• Product Name: O-(5'-O-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) N,N-diethylthiophosphoramidite
• CAS NO: 127105-12-8
• Molecular Weight: 732.838
• Mol File: 127105-12-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: O-(5'-O-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) N,N-diethylthiophosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: O-(5'-O-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) N,N-diethylthiophosphoramidite(127105-12-8)
• EPA Substance Registry System: O-(5'-O-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) N,N-diethylthiophosphoramidite(127105-12-8)

Safety Data

• Hazardous Substances Data: 127105-12-8(Hazardous Substances Data)

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 1001-58-7 3-mercaptopropionitrile 
• 104655-76-7 5'-O-dimethoxytrityl thymidine 3'-O-phosphorbisdiethylamidite 

Relevant articles and documents

Deoxyribonucleoside Phosphorodithioates. Preparation of Dinucleoside Phosphorodithioates from Nucleoside Thiophosphoramidites

A series of protected thymidine thiophosphoramidites have been prepared and their properties evaluated.Although less reactive than phosphoramidites, thiophosphoramidites with small N-substituents (methyl) are useful synthons for the preparation of nucleoside phosphorodithioates, as demonstrated by the preparation of a thymidine dimer.The coupling reactions are not as clean as those of the analogous phosphoramidites since the alkylthio group is somewhat labile.