127181-21-9

Basic information

• Product Name: (1S,5R)-methyl 2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate
• CAS NO: 127181-21-9
• Molecular Weight: 156.138
• Mol File: 127181-21-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (1S,5R)-methyl 2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,5R)-methyl 2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate(127181-21-9)
• EPA Substance Registry System: (1S,5R)-methyl 2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate(127181-21-9)

Safety Data

• Hazardous Substances Data: 127181-21-9(Hazardous Substances Data)

Upstream product

• 136338-56-2 dimethyl 2(R)-(tetrahydropyranyl) hydroxymethyl cyclopropane 1,1-dicarboxylate 
• 51594-55-9 (R)-(-)-epichlorohydrin 
• 108-59-8 malonic acid dimethyl ester 
• 115314-14-2 (2s)-(+)-glycidyl 3-nitrobenzenesulfonate 
• 115314-14-2 (R)-glycidyl nosylate 
• 136338-56-2 dimethyl 2-(tetrahydropyranyl) hydroxymethyl cyclopropane 1,1-dicarboxylate 
• 1440528-08-4 C₁₉H₁₈O₄S 

Downstream Products

• 125876-15-5 (1S,2R)-1-amino-2-(hydroxymethyl)cyclopropanecarboxylic acid 

Relevant articles and documents

CsF in organic synthesis. A convenient synthesis of cyclopropanolactone from glycidyl nosylate

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Dimeric TADDOL Phosphoramidites in Asymmetric Catalysis: Domino Deracemization and Cyclopropanation of Sulfonium Ylides

A gold-catalyzed asymmetric cyclopropanation of unactivated olefins with sulfonium ylides in the presence of a bimetallic catalyst with a novel dimeric TADDOL-phosphoramidite ligand is reported. This transformation allows a rare gold-catalyzed dynamic deracemization of chiral racemic substrates, where the same catalyst is responsible for several synergistic tasks in solution. The products are useful building blocks in synthesis and enable expeditious access to natural products.

Total synthesis of (+)-linoxepin by utilizing the catellani reaction

Molecular intelligence: The structurally novel lignan (+)-linoxepin is synthesized in an eight-step sequence. The enantioselective synthesis features the palladium-catalyzed Catellani reaction as the key step. In this highly convergent multicomponent reaction, two new carbon-carbon bonds are formed, one of which results from a C-H bond functionalization. Copyright