127182-43-8 Usage
Description
6-O-methyl-N-demethylerythromycin A 9-oxime is a semi-synthetic macrolide antibiotic derivative of Erythromycin, which is a large-ring lactone antibiotic with a macrocyclic structure. It is known for its broad-spectrum antimicrobial activity and is used to treat various bacterial infections.
Used in Pharmaceutical Industry:
6-O-methyl-N-demethylerythromycin A 9-oxime is used as an antibiotic for treating a wide range of bacterial infections, including respiratory tract infections, skin infections, and sexually transmitted diseases. Its semi-synthetic nature allows for modifications to improve its pharmacokinetic properties, such as increased bioavailability and reduced side effects.
Used in Research and Development:
6-O-methyl-N-demethylerythromycin A 9-oxime is used as a research compound for studying the structure-activity relationships of macrolide antibiotics and their mechanisms of action. This knowledge can be applied to the development of new and more effective antimicrobial agents to combat drug-resistant bacteria.
Used in Drug Resistance Studies:
6-O-methyl-N-demethylerythromycin A 9-oxime is used in research to understand the mechanisms of bacterial resistance to macrolide antibiotics. This information can help in the development of strategies to overcome resistance and improve the effectiveness of existing treatments.
Used in Veterinary Medicine:
6-O-methyl-N-demethylerythromycin A 9-oxime is used as a veterinary antibiotic for treating bacterial infections in animals, such as livestock and pets. Its broad-spectrum activity makes it suitable for treating various infections in different animal species.
Used in Combination Therapy:
6-O-methyl-N-demethylerythromycin A 9-oxime can be used in combination with other antibiotics or antimicrobial agents to enhance their effectiveness and overcome resistance. This approach can be particularly useful in treating complex or drug-resistant infections.
Check Digit Verification of cas no
The CAS Registry Mumber 127182-43-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,1,8 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 127182-43:
(8*1)+(7*2)+(6*7)+(5*1)+(4*8)+(3*2)+(2*4)+(1*3)=118
118 % 10 = 8
So 127182-43-8 is a valid CAS Registry Number.
127182-43-8Relevant articles and documents
CHEMICAL MODIFICATION OF ERYTHROMYCINS. VIII. A NEW EFFECTIVE ROUTE TO CLARITHROMYCIN (6-O-METHYLERYTHROMYCIN A)
Watanabe, Yoshiaki,Adachi, Takashi,Asaka, Toshifumi,Kashimura, Masato,Morimoto, Shigeo
, p. 2121 - 2124 (2007/10/02)
Selective O-methylation of the C-6 hydroxyl group of erythromycin A could be satisfactorily achieved by using its 9-oxime derivatives as the starting materials.Thus, 6-O-methylerythromycin A (clarithromycin) was synthesized from 2'-O-,3'-N-bis(benzyloxycarbonyl)-N-demethylerythromycin A via its 9-oxime derivative by 6 steps.
