127201-31-4

Basic information

• Product Name: 3-iodobenzeneethanol
• Synonyms: 3-iodobenzeneethanol
• CAS NO: 127201-31-4
• Molecular Weight: 248.063
• Mol File: 127201-31-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-iodobenzeneethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-iodobenzeneethanol(127201-31-4)
• EPA Substance Registry System: 3-iodobenzeneethanol(127201-31-4)

Safety Data

• Hazardous Substances Data: 127201-31-4(Hazardous Substances Data)

Upstream product

• 52022-77-2 2-(3-nitrophenyl)ethanol 
• 52273-77-5 2-(3-aminophenyl)ethan-1-ol 
• 1878-69-9 3-iodophenylacetic acid 

Downstream Products

• 127264-12-4 2-(3-iodophenyl)ethyl bromide 
• 1033705-93-9 2-[3-(6-benzyloxy-pyridazin-3-ylethynyl)-phenyl]-ethanol 
• 645-59-0 dihydrocinnamonitrile 
• 484065-64-7 3-(2-chloroethyl)benzonitrile 
• 1222140-60-4 3-[((2S)-azetidinyl)methoxy]-5-[3-[2-(benzyloxy)ethyl]phenyl]pyridine 
• 1222138-95-5 3-[3-[2-(benzyloxy)ethyl]phenyl]-5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]pyridine 
• 1222134-87-3 2-[3-[5-[(2(S)-azetidinyl)methoxy]-3-pyridyl]phenyl]ethanol 
• 1222138-81-9 2-[3-[5-[[1-(benzyloxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]ethanol 
• 1222138-93-3 1-[2-(benzyloxy)ethyl]-3-iodobenzene 

Relevant articles and documents

Iodinated Choline Transport-Targeted Tracers

We present a novel series of radioiodinated tracers and potential theranostics for diseases accompanied by pathological function of proteins involved in choline transport. Unlike choline analogues labeled with 11C or 18F that are currently used in the clinic, the iodinated compounds described herein are applicable in positron emission tomography, single-photon emission computed tomography, and potentially in therapy, depending on the iodine isotope selection. Moreover, favorable half-lives of iodine isotopes result in much less challenging synthesis by isotope exchange reaction. Six of the described compounds were nanomolar ligands, and the best compound possessed an affinity 100-fold greater than that of choline. Biodistribution data of 125I-labeled ligands in human prostate carcinoma bearing (PC-3) mice revealed two compounds with a biodistribution profile superior to that of [18F]fluorocholine.

NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF

The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.

QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS

Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.