1272542-25-2

Basic information

• Product Name: 1-Benzyloxy-3-(pentafluorosulfanyl)benzene
• Synonyms: 1-Benzyloxy-3-(pentafluorosulfanyl)benzene;[3-(Phenylmethoxy)phenyl]sulfur pentafluoride
• CAS NO: 1272542-25-2
• Molecular Weight: 310.288
• Mol File: 1272542-25-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Benzyloxy-3-(pentafluorosulfanyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyloxy-3-(pentafluorosulfanyl)benzene(1272542-25-2)
• EPA Substance Registry System: 1-Benzyloxy-3-(pentafluorosulfanyl)benzene(1272542-25-2)

Safety Data

• Hazardous Substances Data: 1272542-25-2(Hazardous Substances Data)

Usage

Structure

Benzene derivative with a pentafluorosulfanyl group attached to the third carbon atom and a benzyloxy group attached to the first carbon atom.

Functional groups

Pentafluorosulfanyl (SF5) and benzyloxy (C6H5-CH2-O-) groups.

Applications

Used in organic synthesis as a versatile building block for the preparation of various biologically active molecules and materials.

Unique properties

The pentafluorosulfanyl group imparts unique properties to the molecule, making it useful for the development of new drugs, agrochemicals, and materials with enhanced properties.

Further functionalization

The benzyloxy group provides a handle for further functionalization, allowing for the modification and optimization of the compound for specific applications.

Upstream product

• 2613-26-5 3-nitrophenylsulfur pentafluoride 
• 100-51-6 benzyl alcohol 
• 672-30-0 (3-bromophenyl)pentafluoro-λ⁶-sulfane 
• 286947-67-9 pentafluoro(3-iodophenyl)-λ⁶-sulfane 

Relevant articles and documents

DIARYLIODONIUM SALT

PROBLEM TO BE SOLVED: To provide a compound that allows easy introduction of a pentafluorosulfanylaryl group into a compound of interest. SOLUTION: A diaryliodonium salt is represented by the general formula (d) in the figure. (In the formula, k is 1 or 2, R1 is an alkyl group having 1 or 2 carbon atoms, m is an integer from 0 to 4, R2 is a straight or branched alkyl group having 1 to 4 carbon atoms, n is an integer from 0 to 5, and A- is a counter anion.) SELECTED DRAWING: None COPYRIGHT: (C)2016,JPO&INPIT

Synthesis of Diaryliodonium Salts Having Pentafluorosulfanylarenes and Their Application to Electrophilic Pentafluorosulfanylarylation of C-, O-, N-, and S-Nucleophiles

Novel reagents for the electrophilic introduction of pentafluorosulfanyl (SF5) arenes into target molecules are disclosed. Unsymmetrical diaryliodonium salts 1 having SF5-arenes were synthesized by a one-pot process from iodo-SF5-benzenes 2 in good yields. The SF5-aryliodonium salts 1 were found to be efficient for the electrophilic SF5-arylation of carbon and heterocentered nucleophiles to furnish the corresponding substituted SF5-arenes in good to high yields.

SNAr reactions of nitro-(pentafluorosulfanyl)benzenes to generate SF5 aryl ethers and sulfides

Nucleophilic aromatic substitution of the nitro group of para- and meta-nitro-(pentafluorosulfanyl)benzene with alkoxides and thiolates generates a range of substituted 4- and 3-(pentafluorosulfanyl)benzenes in a single-step reaction.