1272673-95-6Relevant articles and documents
Discovery of pyridones as oral AMPK direct activators
Mirguet, Olivier,Sautet, Stephane,Clement, Catherine-Anne,Toum, Jeroime,Donche, Frederic,Marques, Celine,Rondet, Emilie,Pizzonero, Mathieu,Beaufils, Benjamin,Dudit, Yann,Huet, Pascal,Trottet, Lionel,Grondin, Pascal,Brusq, Jean-Marie,Boursier, Eric,Saintillan, Yannick,Nicodeme, Edwige
supporting information, p. 632 - 636 (2013/07/26)
AMP-activated protein kinase (AMPK) is an evolutionarily conserved fuel-sensing enzyme that is activated in shortage of energy and suppressed in its surfeit. AMPK activation stimulates fatty acid oxidation, enhances insulin sensitivity, alleviates hypergl
PYRROLO [3, 2 -D] PYRIMIDIN-3 -YL DERIVATIVES USED AS ACTIVATORS OF AMPK
-
Page/Page column 39, (2011/11/30)
The present invention relates to pyrrolopyrimidones compounds of the formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds as activators of AMPK.