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127279-72-5

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127279-72-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 127279-72-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,2,7 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 127279-72:
(8*1)+(7*2)+(6*7)+(5*2)+(4*7)+(3*9)+(2*7)+(1*2)=145
145 % 10 = 5
So 127279-72-5 is a valid CAS Registry Number.

127279-72-5Upstream product

127279-72-5Downstream Products

127279-72-5Relevant articles and documents

Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake

Kline Jr.,Wright,Fox,Eldefrawi

, p. 2024 - 2027 (1990)

3-Arylecgonine analogues were synthesized and characterized by 1H and 13C NMR, IR, and MS. The compounds were synthesized as racemates from cycloheptatriene-7-carboxylic acid or enantiomerically from (-)-cocaine. These analogues were tested for their ability to inhibit [3H]cocaine binding to bovine striatal tissue and to inhibit [3H]dopamine uptake into striatal synaptosomes. Methyl (1RS-2-exo-3-exo)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate was the most potent analogue. IC50 values for inhibition of cocaine binding and dopamine uptake were 20 and 100 nM, respectively. The racemates and the 1R isomers were equally potent inhibitors of binding and uptake. Methyl (1RS-2-endo-3-exo)-3-(2,4-dinitrophenyl)-8-methyl-8- azabicyclo[3.2.1]octane-2-carboxylate was the least potent. IC50 for inhibition of both binding and uptake was 40 μM.

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