1273191-44-8

Basic information

• Product Name: di-tert-butyl iodomethyl phosphate
• Synonyms: di-tert-butyl iodomethyl phosphate
• CAS NO: 1273191-44-8
• Molecular Weight: 350.134
• Mol File: 1273191-44-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: di-tert-butyl iodomethyl phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: di-tert-butyl iodomethyl phosphate(1273191-44-8)
• EPA Substance Registry System: di-tert-butyl iodomethyl phosphate(1273191-44-8)

Safety Data

• Hazardous Substances Data: 1273191-44-8(Hazardous Substances Data)

Upstream product

• 33494-80-3 potassium di-tert-butylphosphate 
• 117184-52-8 iodomethyl 4-methylbenzenesulfonate 

Downstream Products

• 1383139-19-2 Di-tert-butyl [2-{[(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetyl]imino}-4-[3-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-3(2H)-yl]methyl phosphate 

Relevant articles and documents

Development of efficient processes for the preparation of Di-tert-butyl potassium phosphate and Di-tert-butyl (Chloromethyl) phosphate

A new and efficient process to prepare di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs, from chloromethyl chlorosulfate (CMCS) and di-tert-butyl potassium phosphate (DTBPP) is described. To develop a process to this important compound with overall efficiency, an improved synthesis of DTBPP was required. The two-step process to DTBPP starts from PCl3 and leverages a H2O 2/catalytic KI mediated oxidation of di-tert-butyl phosphite to provide DTBPP in 81% yield and high purity. In the development of the new process to di-tert-butyl (chloromethyl) phosphate, a comparison to the corresponding tosylate derivative was made. A rational selection of base, phase-transfer catalyst (PTC), and stabilizing additive minimized CMCS decomposition and led to an optimized yield (90% solution yield), improved product purity, and identification of a technique to enable the long-term storage of di-tert-butyl (chloromethyl) phosphate.