127368-56-3

Basic information

• Product Name: (Benzyl-{(R)-3-(1H-indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionyl}-amino)-acetic acid ethyl ester
• Synonyms: (Benzyl-{(R)-3-(1H-indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionyl}-amino)-acetic acid ethyl ester
• CAS NO: 127368-56-3
• Molecular Weight: 534.615
• Mol File: 127368-56-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Benzyl-{(R)-3-(1H-indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionyl}-amino)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Benzyl-{(R)-3-(1H-indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionyl}-amino)-acetic acid ethyl ester(127368-56-3)
• EPA Substance Registry System: (Benzyl-{(R)-3-(1H-indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionyl}-amino)-acetic acid ethyl ester(127368-56-3)

Safety Data

• Hazardous Substances Data: 127368-56-3(Hazardous Substances Data)

Upstream product

• 127369-22-6 {Benzyl-[(R)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-amino}-acetic acid ethyl ester 
• 5241-64-5 Boc-D-Trp-OH 
• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 6480-68-8 quinoline-3-carboxylic acid 
• 136631-77-1 {[(R)-2-Amino-3-(1H-indol-3-yl)-propionyl]-benzyl-amino}-acetic acid ethyl ester; hydrochloride 

Relevant articles and documents

Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors

The intriguing structural similarities of glutamic acid based cholecystokinin (CCK) antagonists (A-64718 and A-65186) and the benzodiazepine CCK antagonist MK-329 (L-364,718) have been reported. Efforts to include the weak CCK antagonist benzotript into this construct utilizing a similar approach have resulted in a novel series of benzotript-based hybrid antagonists N(α)-(3'-quinolylcarbonyl)-(R)-tryptophan di-n-pentylamide (9, A-67396), N(α)-(4',8'-dihydroxy-2'-quinolylcarbonyl)-(R)-tryptophan di-n-pentylamide (23, A-70276), and N(α)-(3'-quinolylcarbonyl)-(R)-5'-hydroxytryptophan di-n-pentylamide (36, A-71134) which possess respectively binding affinities of 23, 21, and 11 nM for the pancreatic CCK-A receptor and which inhibit CCK8-induced amylase secretion. Compound 9 possesses a selectivity of > 500-fold for the pancreatic CCK-A receptor over the CCK-B receptor.