127404-73-3

Basic information

• Product Name: (3E)-4-(4-methoxyphenyl)but-3-enoic acid
• Synonyms: (3E)-4-(4-methoxyphenyl)but-3-enoic acid
• CAS NO: 127404-73-3
• Molecular Weight: 192.214
• Mol File: 127404-73-3.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: (3E)-4-(4-methoxyphenyl)but-3-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3E)-4-(4-methoxyphenyl)but-3-enoic acid(127404-73-3)
• EPA Substance Registry System: (3E)-4-(4-methoxyphenyl)but-3-enoic acid(127404-73-3)

Safety Data

• Hazardous Substances Data: 127404-73-3(Hazardous Substances Data)

Upstream product

• 6399-81-1 triphenylphosphine hydrobromide 
• 123-11-5 4-methoxy-benzaldehyde 
• 1530-44-5 (2-carboxyethyl) triphenylphosphoniumbromide 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 625-38-7 but-3-enoic acid 
• 1950-68-1 4-methoxybenzenesulfonyl hydrazide 
• 64-18-6 formic acid 
• 53484-50-7 p-methoxycinnamyl alcohol 
• 51410-44-7 1-(4-methoxylphenyl)-2-propen-1-ol 
• 53484-50-7 (E)-p-methoxy-cinnamyl alcohol 
• 207120-89-6 (E)-4-(4-methoxyphenyl)but-3-enal 
• 405516-53-2 (E)-1-chloro-4-(4-methoxyphenyl)-1-(phenylsulfinyl)but-3-ene-2-ol 
• 24680-50-0 4-methoxy-trans-cinnamaldehyde 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 

Downstream Products

• 689257-49-6 (N-methoxy-N-methyl)-4-(p-methoxyphenyl)but-3-enamide 
• 92587-78-5 trans-4-(p-methoxyphenyl)-3-buten-1-ol 
• 1142924-04-6 C₁₁H₁₂O₄ 
• 1613157-52-0 (4R,5S)-4-amino-5-(4-methoxyphenyl)dihydrofuran-2(3H)-one 
• 1613157-53-1 tert-butyl ((2S,3R)-2-(4-methoxyphenyl)-5-oxotetrahydrofuran-3-yl)carbamate 
• 126800-59-7 (S)-3-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)butanoic acid 
• 1613157-30-4 N-((2S,3R)-2-(4-methoxyphenyl)-5-oxotetrahydrofuran-3-yl)-4-nitrobenzenesulfonamide 
• 192701-83-0 methyl 5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate 

Relevant articles and documents

Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives

We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.

Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles

Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in yields of up to 95percent. The reactions are operationally simple, use readily available starting materials, require no intervention of a catalyst, and enable the synthesis of mono-, di- A nd tri-substituted pyrazoles. With the ability to produce highly substituted pyrazoles and the flexibility in installing various types of substituents, this method constitutes a new entry to this valuable heterocyclic scaffold and may be of interest to all branches of the chemical industry.

HFIP Solvent Enables Alcohols to Act as Alkylating Agents in Stereoselective Heterocyclization

A new method for the stereoselective synthesis of highly functionalized oxygen heterocycles using allyl or benzyl alcohols as alkylating agents is presented. The process is efficient and atom economic, generating water as the only stoichiometric byproduct. Substoichiometric amounts of Ti(OiPr)4 in HFIP solvent are key to this reactivity, and the method tolerates a broad substitution pattern on both the alcohol initiator and homoallylic alcohol substrate. Preliminary mechanistic studies reveal in situ formation of a titanium complex with HFIP which may initiate the cyclization reaction. Further stereoselective functionalization of the products allows access to a diverse range of interesting heterocyclic structures.