127407-54-9

Basic information

• Product Name: (S)-2-t-butoxycarbonylamino-3-benzyloxy-1-methanesulfonyloxypropane
• Synonyms: (S)-2-t-butoxycarbonylamino-3-benzyloxy-1-methanesulfonyloxypropane
• CAS NO: 127407-54-9
• Molecular Weight: 359.444
• Mol File: 127407-54-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-2-t-butoxycarbonylamino-3-benzyloxy-1-methanesulfonyloxypropane(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-t-butoxycarbonylamino-3-benzyloxy-1-methanesulfonyloxypropane(127407-54-9)
• EPA Substance Registry System: (S)-2-t-butoxycarbonylamino-3-benzyloxy-1-methanesulfonyloxypropane(127407-54-9)

Safety Data

• Hazardous Substances Data: 127407-54-9(Hazardous Substances Data)

Upstream product

• 23680-31-1 BOC-O-benzyl-L-serine 
• 66866-45-3 C₂₀H₂₉NO₇ 
• 80963-10-6 methyl O-benzyl-N-(tert-butoxycarbonyl)-L-serinate 
• 79069-15-1 N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol 
• 124-63-0 methanesulfonyl chloride 
• 79069-15-1 tert-butyl N-[(1S)-1-(benzyloxymethyl)-2-hydroxy-ethyl]carbamate 

Downstream Products

• 167421-97-8 1-benzyloxy-2(S)-t-butoxycarbonylamino-3-ethylthiopropane 
• 153782-99-1 ((S)-2-Benzyloxy-1-chloromethyl-ethyl)-carbamic acid tert-butyl ester 
• 126301-34-6 (S)-2-amino-3-benzyloxypropanesulphonic acid 
• 79069-13-9 (R)-2-tertbutoxycarbonylamino-1-propanol 
• 178761-57-4 (R)-N¹-(2-Amino-ethyl)-3-benzyloxy-propane-1,2-diamine 
• 178761-50-7 3-aza-5-amino-1-(R)-benzyloxymethyl-1-(t-butoxycarbonylamino)pentane 
• 126301-25-5 (S)-2-amino-3-benzyloxypropyl methanesulphonate hydrochloride 

Relevant articles and documents

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

The present invention comprises glucosylceramide synthase (GCS) inhibitors of structural formula (I), and pharmaceutically acceptable salts thereof, wherein R1, E, A, L, X1, Q, R4, R5, m and n, are as defined he

Synthesis of enantiomerically pure 1-(R)- and 1-(S)-hydroxymethyl-DTPA penta-t-butyl esters via chiral aminoalcohols

A convenient synthesis of enantiomerically enriched 1-hydroxymethyl-DTPA (diethylenetriamine pentaacetic acid) penta-t-butyl esters 3 has been achieved for the preparation of chiral synthones of new paramagnetic gadolinium complexes.

Syntheses and Properties of Optically Active 2-Substituted Taurines

The synthesis of nine 2-substituted taurines (5a-i), including the marine natural product D-cysteinolic acid (5f), are described.These involve the successive conversion of N-t-butoxycarbonyl(Boc)-protected amino acid esters (1) into the N-Boc-2-aminoethanols (2), their O-mesylated derivatives (3), the deprotected 2-aminoethyl methanesulphonates (4), followed by the replacement of the mesyloxy group by a sulpho group to give the optically active taurines (5a-e,g-i).Hydrogenolysis of 2-benzyloxymethyltaurine (5e) gives D-cysteinolic acid (5f).The structure of another of the products, (5b), is also confirmed by an alternative synthesis from N-Boc-valine methyl ester (1b) via twoβ-bromoethylamine derivatives, (6b) and (7b).