127427-45-6

Basic information

• Product Name: 2-bromo-2,2-difluoro-N-phenyl-acetamide
• Synonyms: 2-bromo-2,2-difluoro-N-phenyl-acetamide
• CAS NO: 127427-45-6
• Molecular Weight: 250.043
• Mol File: 127427-45-6.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 2-bromo-2,2-difluoro-N-phenyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-2,2-difluoro-N-phenyl-acetamide(127427-45-6)
• EPA Substance Registry System: 2-bromo-2,2-difluoro-N-phenyl-acetamide(127427-45-6)

Safety Data

• Hazardous Substances Data: 127427-45-6(Hazardous Substances Data)

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 91-59-8 naphthalen-2-ylamine 
• 62-53-3 aniline 

Relevant articles and documents

Visible Light/Tertiary Amine Promoted Synergistic Hydroxydifluoroacetamidation of Unactivated Alkenes under Air

An efficient and novel method for regioselective hydroxydifluoroacetamidation of alkenes with bromodifluoroacetamides has been achieved via a tandem radical pathway mediated by photoredox catalysis under metal-free conditions. This transformation proceeded smoothly in the presence of Rhodamine 6G, affording a series of α,α-difluoro-γ-hydroxyacetamides in moderate to excellent yields. The significant advantages of this protocol are the low-cost photocatalyst, readily available starting materials, synthetic convenience, and wide functional group compatibility.

The reaction of fluorine-containing compounds with conjugated dienoic acids initiated by sodium dithionite

The reaction of fluorine-containing halides and acetamides with conjugated dienoic acids initiated by sodium dithionite gave halide-free 1,4-adducts in 40-80% yields, with the E configuration as the major products.

Copper-Catalyzed Radical Difluoroalkylation and Redox Annulation of Nitroalkynes for the Construction of C2-Tetrasubstituted Indolin-3-ones

An efficient and convenient method with wide applicability for the synthesis of C2-tetrasubstituted indolin-3-ones via copper-catalyzed redox cycloisomerization of nonprefunctionalized nitroalkynes has been developed. This protocol features simple operati

Visible Light-Promoted Radical Relay Cyclization/C-C Bond Formation of N-Allylbromodifluoroacetamides with Quinoxalin-2(1 H)-ones

A visible light-promoted radical relay of N-allylbromodifluoroacetamide with quinoxalin-2(1H)-ones was developed in which 5-exo-trig cyclization and C-C bond formation were involved. This protocol was performed under mild conditions to facilely offer a variety of hybrid molecules bearing both quinoxalin-2(1H)-one and 3,3-difluoro-γ-lactam motifs. These prepared novel skeletons would expand the accessible chemical space for structurally complex heterocycles with potential biological activities.

Photoinduced EDA Complexes Enabled Radical Tandem Cyclization/Arylation of Unactivated Alkene with 2-Amino-1,4-naphthoquinones

A visible-light-induced radical tandem cyclization/arylation between 2-amino-1, 4-naphthoquinone and N-allyl-2-bromo-2,2-difluoroacetamides has been developed without an external photocatalyst. The transformation could be carried out at room temperature a