127431-10-1

Basic information

• Product Name: 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone
• Synonyms: 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone
• CAS NO: 127431-10-1
• Molecular Weight: 384.432
• Mol File: 127431-10-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone(127431-10-1)
• EPA Substance Registry System: 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone(127431-10-1)

Safety Data

• Hazardous Substances Data: 127431-10-1(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 72326-72-8 2-bromo-3,4,5-trimethoxy-1-methylbenzene 
• 6443-69-2 3,4,5-trimethoxytoluene 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 127430-84-6 1-(chloromethyl)-2,3,4,5-tetramethoxy-6-methylbenzene 
• 202843-56-9 2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone 
• 13754-38-6 N-Benzoylpiperazine 

Relevant articles and documents

Efficient synthesis and antioxidant activities of N-heterocyclyl substituted Coenzyme Q analogues

A new strategy for the efficient synthesis of C-5 heterocyclyl substituted Coenzyme Q analogues was developed by N-alkylation of bromomethylated quinone 11 with a series of amines 12 under metal-free conditions. In vitro antioxidant activities of these Coenzyme Q analogues were evaluated and compared with commercial antioxidant Coenzyme Q10 by employing DPPH assay. All these N-heterocyclyl substituted Coenzyme Q analogues are found to be exhibiting good antioxidant properties and may be used as potent antioxidants for combating oxidative stress.

Alternative synthesis of 2-(4-benzoyl-piperazin-1-ylmethyl)-5, 6-dimethoxy-3-methyl-[1, 4]benzoquinone

The title compound was prepared by a reaction sequence starting from 2, 3, 4, 5-tetramethoxytoluene via Blanc chloromethylation reaction, oxidation and alkylation. The described method provides a good yield of the heterocyclic- Coenzyme Q analogue and is