127446-34-8

Basic information

• Product Name: N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide
• Synonyms: N-(6-Chloro-3-formylpyridin-2-yl)pivalamide;N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide
• CAS NO: 127446-34-8
• Molecular Formula: C₁₁H₁₃ClN₂O₂
• Molecular Weight: 240.68612
• Mol File: 127446-34-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 137-139℃
• Boiling Point: 428.644 °C at 760 mmHg
• Flash Point: 213.037 °C
• Appearance: /
• Density: 1.273
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide(127446-34-8)
• EPA Substance Registry System: N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide(127446-34-8)

Safety Data

• Hazardous Substances Data: 127446-34-8(Hazardous Substances Data)

Usage

General Description

N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide is a chemical compound with the molecular formula C14H16ClN3O2. It is a pyridine derivative with a formyl group and a chloro substituent attached to the pyridine ring. The compound also contains a 2,2-dimethyl-propionamide moiety. This chemical may have various applications in the pharmaceutical or agrochemical industries, potentially serving as a building block for the synthesis of more complex molecules or as a starting material for the development of new drugs or pesticides. Its specific properties, potential uses, and safety considerations would need to be further evaluated in a specific context.

Upstream product

• 4394-85-8 4-morpholinecarboxaldehyde 
• 86847-84-9 2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide 
• 3282-30-2 pivaloyl chloride 
• 45644-21-1 6-chloropyridin-2-amine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 294659-83-9 7-chloro-3-(2,6-dichlorophenyl)-1-methyl-1,8-naphthyridin-2(1H)-one 
• 294659-82-8 7-chloro-3-(2,6-dichlorophenyl)-1,8-naphthyridin-2(1H)-one 
• 294659-81-7 7-chloro-3-(2,6-dichlorophenyl)-1,8-naphthyridin-2-amine 
• 294659-79-3 7-amino-6-(2,6-dichlorophenyl)-1,8-naphthyridin-2(1H)-one 
• 294659-80-6 7-acetamido-6-(2,6-dichlorophenyl)-1,8-naphthyridin-2(1H)-one 
• 846036-36-0 N-[6-(4-benzyloxy-butoxy)-3-formyl-pyridin-2-yl]-2,2-dimethyl-propionamide 
• 294659-78-2 3-(2,6-dichlorophenyl)-7-(2-ethoxyethoxy)-1,8-naphthyridin-2-amine 
• 1144040-47-0 (E)-N-[6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-yl]-2,2-dimethyl-propionamide 
• 1436416-04-4 N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide 
• 1436416-05-5 N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide 
• 1436416-06-6 C₁₆H₁₇N₃O₂ 
• 1349829-83-9 ethyl 2-(6-((2R,5R)-2-methyl-5-phenylmorpholino)-2-pivalamidopyridin-3-yloxy)acetate 
• 1349829-81-7 N-(3-hydroxy-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide 
• 1349829-77-1 6-((2R,5R)-2-methyl-5-phenylmorpholino)-2H-pyrido[3,2-b]-[1,4]oxazin-3(4H)-one 

Relevant articles and documents

NEW ANTIBACTERIAL COMPOUNDS

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FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS

The present invention relates to novel functionally selective ligands of dopamine D2 receptors, including agonists, antagonists, and inverse agonists. The invention further relates to the use of these compounds for treating central nervous system disorders related to D2 receptors.

Synthesis and structure-activity relationships of 7-substituted 3-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as selective inhibitors of pp60(c-src)

7-Substituted 3-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones are potent inhibitors of protein tyrosine kinases, with some selectivity for c-Src. The compounds were prepared by condensing 4,6-diaminonicotinaldehyde with 2,6-dichlorophenylacetonitrile and selectively converting the 2- and 7-amino groups of the product to hydroxy and fluoro groups, respectively, by prolonged diazotization in 50% aqueous fluoboric acid. N-Methylation, followed by treatment with aliphatic diamines, aromatic amines, or their derived lithium anions, gave the desired compounds. Selected isomeric 1,8-naphthyridin-2(1H)-ones were also prepared in order to evaluate the relative contributions of both ring A aza atoms of the related pyrido[2,3-d]pyrimidin-7(8H)-ones to the inhibitory activity. The compounds were evaluated for their ability to prevent phosphorylation of a model substrate by c-Src, FGF-1 receptor, and PDGF-β receptor enzymes. Overall, there was a high degree of correlation of the activities against the different kinases, with c-Src being generally the most sensitive to structural changes. 1,6-Naphthyridin-2(1H)-one analogues bearing basic aliphatic side chains [7-NH(CH2)(n)NRR, 7-NHPhO(CH2)(n)NRR, or 7-NHPhN(CH2)4NMe] were the most potent against c-Src (IC50s of 10-80 nM), showing good selectivity with respect to PDGFR (10-300-fold) but less with respect to FGFR. The 1,6-naphthyridin-2(1H)-ones showed broadly similar activity to the analogous pyrido[2,3-d]-pyrimidin-7(8H)-ones, whereas the 1,8-naphthyridin-2(1H)-ones were at least 103-fold less potent. These results, indicating that the 3-aza atom in the pyrido[2,3-d]pyrimidin-7(8H)-ones is mandatory, whereas the 1-aza atom is not, support the published binding model for these compounds to c-Src (J. Med. Chem. 1998, 41, 1752), where the 3-aza and 2-NH atoms form a bidentate H-bond donor - acceptor motif that interacts with Met341 and the 1-aza atom is not involved in specific binding interactions.