127502-66-3Relevant articles and documents
Synthesis of (-)-Piperitylmagnolol Featuring ortho-Selective Deiodination and Pd-Catalyzed Allylation
Ikoma, Atsushi,Ogawa, Narihito,Kondo, Daiki,Kawada, Hiroki,Kobayashi, Yuichi
, p. 2074 - 2077 (2016)
A 1,4-addition strategy using an enone and a copper reagent was studied for the synthesis of (-)-piperitylmagnolol. A MOM-protected biphenol copper reagent was added to BF3·OEt2-activated 4-isopropylcyclohexenone, whereas 1,4-addition of protected monophenol reagents possessing an allyl group was found to be unsuccessful. The allyl group was later attached to the p-,p′-diiodo-biphenol ring by Pd-catalyzed coupling with allylborate. The aforementioned iodide was synthesized using a new method for ortho-selective deiodination of o-,p-diiodophenols.
Arylation of Phenols. Convenient, Regiospecific Methods for Mono- or Bis-p-fluorophenylations, Suitable for Large Scale Syntheses
Jendralla, Heiner,Chen, Li-Jian
, p. 827 - 833 (2007/10/02)
Phenols have been arylated by a palladium(0)-catalyzed coupling reaction.Two methods were used: a Grignard reagent of a protected phenol component 2 was coupled with a haloarene, or an umpolung (reversed reactivity) where unprotected phenolic halides 6 were coupled with aryl Grignard reagents.Bis-arylation and regiospecific ortho-, meta- and para-arylations were achieved.Aryl-aryl-couplings were insensitive to steric hindrance in the Grignard component, but were inhibited by sulfur-containing substituents in the phenolic component.A thiocyanate substituted biaryl was used to synthesize arylated phenols with various sulfur functionalities.
