127516-98-7 Usage
Description
(1E)-1,2-dideoxy-1-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-D-erythro-pent-1-enitol is a chemical compound derived from D-erythro-pent-1-enitol, featuring a dideoxy group and a 5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl moiety. (1E)-1,2-dideoxy-1-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-D-erythro-pent-1-enitol holds potential biological activity and is of interest in pharmaceutical research, although its precise properties and applications require further investigation to determine its safety and efficacy for medicinal or industrial uses.
Uses
Used in Pharmaceutical Research:
(1E)-1,2-dideoxy-1-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-D-erythro-pent-1-enitol is used as a compound of interest for its potential biological activity, primarily in the field of pharmaceutical research. (1E)-1,2-dideoxy-1-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-D-erythro-pent-1-enitol's unique structure suggests it may have applications in the development of new drugs or therapies, although further study is needed to explore these possibilities and to confirm its safety and efficacy for specific medicinal purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 127516-98-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,5,1 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 127516-98:
(8*1)+(7*2)+(6*7)+(5*5)+(4*1)+(3*6)+(2*9)+(1*8)=137
137 % 10 = 7
So 127516-98-7 is a valid CAS Registry Number.
127516-98-7Relevant articles and documents
Synthesis and Anti-HIV Evaluation of 2',3'-Dideoxyribo-5-chloropyrimidine Analogues: Reduced Toxicity of 5-Chlorinated 2',3'-Dideoxynucleosides
Aerschot, Arthur Van,Everaert, Dirk,Balzarini, Jan,Augustyns, Koen,Jie, Liu,at al.
, p. 1833 - 1839 (2007/10/02)
In view of the selective anti-HIV activity of 2',3'-dideoxy-3'-fluoro-5-chlorouridine (11), a series of eight 2',3'-dideoxy-5-chloropyrimidines were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus type 1 (HIV-1) replication in MT-4 cells.A marked improvement in selectivity was noted for the 5-chlorouracil derivatives of 2,3-dideoxyribofuranose, 3-azido-2,3-dideoxyribofuranose, and 3-fluoro-2,3-dideoxyribofuranose, mainly due to decreased toxicity of the compounds for the host cells.While chlorination of 2',3'-dideoxycytidine remo ved the anti-HIV activity, introduction of chlorine at the C-5 position of 3'-fluoro-, 3'-azido- or 2',3'-didehydro-2',3'-dideoxycytidine led to reduced cytotoxicity with only slightly reduced anti-HIV activity.X-ray analysis showed compound 11 to have two molecules in the asymmetric unit with κ = -168.8(3) deg and -131.3(3) deg and P = 179(1) deg and 163(1) deg, respectively; thus revealing no close resemblance to 3'-azido-3'-deoxythymidine (AZT).
