127665-77-4Relevant articles and documents
Concise Seven-Membered Oxepene/Oxepane Synthesis - Structural Motifs in Natural and Synthetic Products
Osei Akoto, Clement,Rainier, Jon D.
, p. 3529 - 3535 (2019/09/07)
This work outlines a suitable method for the synthesis of oxepane skeleton using iterative C-glycoside technology on the oxepene intermediate, which was synthesized utilizing Wilkinson's catalyst [Rh(PPh 3) 3 Cl] to generate the isom
Studies culminating in the total synthesis and determination of the absolute configuration of (-)-saudin
Boeckman Jr., Robert K.,Rosario Ferreira, Maria Rico Del,Mitchell, Lorna H.,Shao, Pengcheng,Neeb, Michael J.,Fang, Yue
, p. 9787 - 9808 (2012/02/05)
A full account of studies that culminated in the total synthesis of both antipodes and the assignment of its absolute configuration of Saudin, a hypoglycemic natural product. Two approaches are described, the first proceeding though bicyclic lactone intermediates and related second monocyclic esters. The former was obtained via asymmetric Diels-Alder cycloaddition and the latter by an asymmetric annulation protocol. Both approaches employ a Lewis acid promoted Claisen rearrangement, with the successful approach taking advantage of bidentate chelation to control the facial selectivity of the key Claisen rearrangement.
Divergent syntheses of resorcylic acid lactones: L-783277, LL-Z1640-2, and hypothemycin
Dakas, Pierre-Yves,Jogireddy, Rajamalleswaramma,Valot, Gaelle,Barluenga, Sofia,Winssinger, Nicolas
supporting information; experimental part, p. 11490 - 11497 (2010/04/28)
The resorcylic acid lactones (RAL) are endowed with diverse biological activity ranging from transcription factor modulators (zearalenone and zearalenol) to HSP90 inhibitors (radicicol and pochonin D) and reversible (aigialomycin D) as well as irreversibl