127666-99-3

Basic information

• Product Name: 2-CHLORO-4-METHOXYBENZONITRILE
• Synonyms: 2-CHLORO-4-METHOXYBENZONITRILE;BUTTPARK 120\07-70;2-chloro-4-(trifluoromethoxy)benzonitrile;2-chloro-4-Methoxy benzene nitrile;3-Chloro-4-cyanoanisole;3-Chloro-4-cyanoanisole, 2-Chloro-p-anisonitrile
• CAS NO: 127666-99-3
• Molecular Formula: C₈H₆ClNO
• Molecular Weight: 167.59
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 127666-99-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 71-75°C
• Boiling Point: 296.588 °C at 760 mmHg
• Flash Point: 133.172 °C
• Appearance: White solid
• Density: 1.253 g/cm³
• Vapor Pressure: 0.00142mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-CHLORO-4-METHOXYBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-METHOXYBENZONITRILE(127666-99-3)
• EPA Substance Registry System: 2-CHLORO-4-METHOXYBENZONITRILE(127666-99-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 127666-99-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-white crystalline

InChI:InChI=1/C8H6ClNO/c1-11-7-3-2-6(5-10)8(9)4-7/h2-4H,1H3

Upstream product

• 3336-16-1 2-chloro-4-hydroxybenzonitrile 
• 74-88-4 methyl iodide 
• 330660-35-0 silver cyanide 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 874-90-8 4-methoxybenzonitrile 
• 54439-75-7 2-chloro-4-methoxybenzaldehyde 
• 67-56-1 methanol 
• 28163-00-0 4-nitro-2-chlorobenzonitrile 

Downstream Products

• 127667-07-6 2-(Cyano-phenyl-methyl)-4-methoxy-benzonitrile 
• 934606-28-7 2-chloro-4-methoxy-N'-hydroxy-benzimidamide 
• 941696-11-3 Ethyl 3-(2-chloro-4-methoxyphenyl)-3-oxopropanoate 
• 863868-23-9 4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaboryl)benzonitrile 
• 868861-17-0 2,4-bis(2-chloro-4-methoxyphenyl)-1-(4-methoxyphenyl)-1H-imidazole 
• 935750-36-0 2-(2-chloro-4-methoxyphenyl)-1,4-bis(4-methoxyphenyl)-5-phenyl-1H-imidazole 
• 935750-30-4 2,4-bis(2-chloro-4-methoxyphenyl)-1-(4-methoxyphenyl)-5-methyl-1H-imidazole 
• 935750-31-5 2-(2-chloro-4-methoxyphenyl)-5-ethyl-1,4-bis(4-methoxyphenyl)-1H-imidazole 
• 935750-28-0 2-(2-chloro-4-methoxyphenyl)-1,4-bis(4-methoxyphenyl)-5-methyl-1H-imidazole 
• 935750-26-8 2-(2-chloro-4-methoxyphenyl)-1,4-bis(4-methoxyphenyl)-1H-imidazole 

Relevant articles and documents

Ligand-Promoted Non-Directed C?H Cyanation of Arenes

This article reports the first example of a 2-pyridone accelerated non-directed C?H cyanation with an arene as the limiting reagent. This protocol is compatible with a broad scope of arenes, including advanced intermediates, drug molecules, and natural products. A kinetic isotope experiment (kH/kD=4.40) indicates that the C?H bond cleavage is the rate-limiting step. Also, the reaction is readily scalable, further showcasing the synthetic utility of this method.

IMIDAZO [1,2A] PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION

The invention is directed to Compounds of Formula (I) as well as methods of making and using the compounds.

SUBSTITUTED QUINOLONES

The invention relates to substituted quinolones methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular, for use as antiviral agents, in particular, against cytomegaloviruses.