127716-25-0Relevant articles and documents
A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED-5-NITROIMIDAZOLE BUILDING BLOCKS
Crozet, Michel P.,Vanelle, Patrice,Jentzer, Olivier,Kaafarani, Mustapha
, p. 7 - 14 (2007/10/02)
The nitration of 1,2-dimethylimidazoles bearing at the C4 position a chain with a tertiary alcohol or a terminal alkene gives rise to 5-nitroimidazoles in which the side chains are converted in β-nitroalcohols.These compounds treated with base to splitt off nitromethane anion afford ketones.This represents a preparatively useful and convenient route to new 4-substituted 5-nitroimidazoles.