127718-28-9

Basic information

• Product Name: 7α-trimethylsilyloxy-6β-(3'α-trimethylsilyloxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-ol
• Synonyms: 7α-trimethylsilyloxy-6β-(3'α-trimethylsilyloxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-ol
• CAS NO: 127718-28-9
• Molecular Weight: 450.723
• Mol File: 127718-28-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7α-trimethylsilyloxy-6β-(3'α-trimethylsilyloxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 7α-trimethylsilyloxy-6β-(3'α-trimethylsilyloxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-ol(127718-28-9)
• EPA Substance Registry System: 7α-trimethylsilyloxy-6β-(3'α-trimethylsilyloxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-ol(127718-28-9)

Safety Data

• Hazardous Substances Data: 127718-28-9(Hazardous Substances Data)

Upstream product

• 871669-30-6 7α-trimethylsilyloxy-6β-(3'-oxo-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one 
• 871669-32-8 7α-hydroxy-6β-(3'-oxo-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one 
• 51638-93-8 7α-hydroxy-6β-(3'-hydroxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one 
• 118457-23-1 7α-hydroxy-6β-hydroxymethylene-2-oxabicyclo<3.3.0>octan-3-one bistrimethylsilyl ether 
• 122517-79-7 7α-trimethylsilyloxy-6β-formyl-2-oxabicyclo<3.3.0>octan-3-one 
• 62961-72-2 Corey aldehyde 
• 127702-12-9 7α-trimethylsilyloxy-6β-(3'α-trimethylsilyloxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one 
• 40665-68-7 dimethyl (3-phenoxy-2-oxopropyl)phosphonate 
• 32233-40-2 (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one 

Downstream Products

• 60325-46-4 Sulprostone 
• 127718-29-0 N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide 
• 79172-00-2 N-(methanesulfonyl)-16-phenox-ω-tetranor-PGF_2α-carboxamide 

Relevant articles and documents

PROSTANOIDS. XXIX. SELECTIVE OXIDATION OF 7α-HYDROXY-6β-HYDROXYMETHYLENE-2-OXABICYCLOOCTAN-3-ONE BISTRIMETHYLSILYL ETHER BY REAGENTS BASED ON CHROMIUM(VI) AS KEY STAGE IN SYNTHESIS OF SULPROSTONE

7α-Hydroxy-6β-(3-oxo-4-phenoxy-1E-butenyl)-2-oxabicyclooctan-3-one was synthesized by the selective oxidation of 7α-hydroxy-6β-hydroxymethylene-2-oxabicyclooctan-3-one bistrimethylsilyl ether with CrO3*2Py/SiO2 and subsequent condensation of the intermediate 7α-trimethylsiloxy-6β-formyl-2-oxabicyclooctan-3-one with dimethyl 2-oxo-3-phenoxypropylphosphonate.The product was then converted into the methanesulfonamide of 16-phenoxy-17,18,19,20-tetranorprostaglandin E2 (sulprostone).