1278444-56-6

Basic information

• Product Name: (R)-1-(tert-butyldiphenylsilyloxy)pent-3-yn-2-ol
• Synonyms: (R)-1-(tert-butyldiphenylsilyloxy)pent-3-yn-2-ol
• CAS NO: 1278444-56-6
• Molecular Weight: 338.522
• Mol File: 1278444-56-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-1-(tert-butyldiphenylsilyloxy)pent-3-yn-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(tert-butyldiphenylsilyloxy)pent-3-yn-2-ol(1278444-56-6)
• EPA Substance Registry System: (R)-1-(tert-butyldiphenylsilyloxy)pent-3-yn-2-ol(1278444-56-6)

Safety Data

• Hazardous Substances Data: 1278444-56-6(Hazardous Substances Data)

Upstream product

• 154698-93-8 2-((tertbutyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide 
• 154698-92-7 methyl 2-((tert-butyl(diphenyl)silyl)oxy)acetate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 76271-74-4 2-((t-butyldiphenylsilyl)oxy)acetic acid 
• 193292-65-8 1-(tert-butyldiphenylsilyloxy)pent-3-yne-2-one 

Downstream Products

• 1278444-60-2 C₁₉H₁₆O₄ 
• 710324-30-4 (4S)-4,5-dihydroxy-2,3-pentanedione 

Relevant articles and documents

An efficient synthesis of the precursor of AI-2, the signalling molecule for inter-species quorum sensing

Autoinducer-2 (AI-2) is a signalling molecule for bacterial inter-species communication. A synthesis of (S)-4,5-dihydroxypentane-2,3-dione (DPD), the precursor of AI-2, is described starting from methyl glycolate. The key step was an asymmetric reduction of a ketone with (S)-Alpine borane. This new method was highly reproducible affording DPD for biological tests without contaminants. The biological activity was tested with the previously available assays and compared with a new method using an Escherichia coli reporter strain thus avoiding the use of the pathogenic Salmonella reporter.