1278509-50-4

Basic information

• Product Name: 2-O-[(tert-butyl)-dimethylsilyl]-1-deoxy-5-O-(4,4'-dimethoxytrityl)-3-(2-cyanoethyl-N,N-diisopropylphosphoramidite)-1-(2,4,6-trifluorophenyl)-β-D-ribofuranose
• CAS NO: 1278509-50-4
• Molecular Weight: 881.057
• Mol File: 1278509-50-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-O-[(tert-butyl)-dimethylsilyl]-1-deoxy-5-O-(4,4'-dimethoxytrityl)-3-(2-cyanoethyl-N,N-diisopropylphosphoramidite)-1-(2,4,6-trifluorophenyl)-β-D-ribofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 2-O-[(tert-butyl)-dimethylsilyl]-1-deoxy-5-O-(4,4'-dimethoxytrityl)-3-(2-cyanoethyl-N,N-diisopropylphosphoramidite)-1-(2,4,6-trifluorophenyl)-β-D-ribofuranose(1278509-50-4)
• EPA Substance Registry System: 2-O-[(tert-butyl)-dimethylsilyl]-1-deoxy-5-O-(4,4'-dimethoxytrityl)-3-(2-cyanoethyl-N,N-diisopropylphosphoramidite)-1-(2,4,6-trifluorophenyl)-β-D-ribofuranose(1278509-50-4)

Safety Data

• Hazardous Substances Data: 1278509-50-4(Hazardous Substances Data)

Upstream product

• 631899-57-5 (2R,3R,4S,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-(2,4,6-trifluoro-phenyl)-tetrahydro-furan 
• 14233-64-8 (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-dihydro-furan-2-one 
• 2367-76-2 2,4,6-trifluorobromobenzene 
• 1278509-45-7 2-O-[(tert-butyl)-dimethylsilyl]-1-deoxy-5-O-(4,4'-dimethoxytrityl)-1-(2,4,6-trifluorophenyl)-β-D-ribofuranose 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 1278509-43-5 1-deoxy-5-O-(4,4'-dimethoxytrityl)-1-(2,4,6-trifluorophenyl)-β-D-ribofuranose 

Relevant articles and documents

Control of the stability of a protein-RNA complex by the position of fluorine in a base analogue

The effects of modifying the electronic characteristics of nonpolar base analogues substituted at positions involved in stacking interactions between SL2 RNA and the U1A protein are described. A surprisingly large difference in the stability between complexes formed with base analogues that differ only in the position of substitution of a single fluorine atom is observed. The results of high-level ab initio calculations of the interactions between the nonpolar base analogue and the amino acid side chain correlate with the experimentally observed trends in complex stability, which suggests that changes in stacking interactions that result from varying the position and degree of fluorine substitution contribute to the effects of fluorine substitution on the stability of the U1A-SL2 RNA complex.