1278585-96-8

Basic information

• Product Name: 4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin
• Synonyms: 4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin
• CAS NO: 1278585-96-8
• Molecular Weight: 597.045
• Mol File: 1278585-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin(1278585-96-8)
• EPA Substance Registry System: 4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin(1278585-96-8)

Safety Data

• Hazardous Substances Data: 1278585-96-8(Hazardous Substances Data)

Upstream product

• 518-28-5 podofilox 
• 117604-05-4 4β-azido-4-deoxy-4′-demethylepipodophyllotoxin 
• 66090-36-6 3-chlorobenzoyl isothiocyanate 
• 117507-84-3 (5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one 
• 6559-91-7 4'-demethylepipodophyllotoxin 

Relevant articles and documents

Synthesis and evaluation of aroylthiourea derivatives of 4-β-amino-4'-O-demethyl-4-desoxypodophyllotoxin as novel topoisomerase II inhibitors

A novel series of aroylthiourea derivatives of 4-β-amino-4′-O- demethyl-4-desoxy- podophyllotoxin were synthesized. Their cytotoxicities against three cancer cell lines were investigated by MTT assay. The kDNA decatenation assay indicated that compounds 5a, 5f, 5h and 5l inhibited topoisomerase II-mediated kDNA decatenation. DNA flow cytometric analysis revealed that compound 5a induced cell cycle arrest at G2/M phase in HCT-116 cell line.