127978-78-3

Basic information

• Product Name: 1-(2-oxopyrrolidin-1-yl)-2-phenylethane-1,2-dione
• Synonyms: 1-(2-oxopyrrolidin-1-yl)-2-phenylethane-1,2-dione
• CAS NO: 127978-78-3
• Molecular Weight: 217.224
• Mol File: 127978-78-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2-oxopyrrolidin-1-yl)-2-phenylethane-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-oxopyrrolidin-1-yl)-2-phenylethane-1,2-dione(127978-78-3)
• EPA Substance Registry System: 1-(2-oxopyrrolidin-1-yl)-2-phenylethane-1,2-dione(127978-78-3)

Safety Data

• Hazardous Substances Data: 127978-78-3(Hazardous Substances Data)

Upstream product

• 616-45-5 2-pyrrolidinon 
• 93-56-1 phenylethane 1,2-diol 
• 98-86-2 acetophenone 
• 1074-12-0 phenylglyoxal hydrate 
• 683246-77-7 N-(2-phenylethynyl)pyrrolidin-2-one 

Relevant articles and documents

Exocyclic N-Acyliminium Ion (NAI) Cyclization: Access to Fully Substituted Oxazoles and Furocoumarins

A concise, one-pot route to oxazoles and furocoumarins has been reported. The key step in this transformation involves in situ generation of N-acyliminium ion (NAI) precursor under catalyst and solvent-free conditions and their further transformations promoted by superacid in the same pot. We have also presented the experimental evidence for the involvement of proto-solvated novel exocyclic N-acyliminium ion. Further, the UV-visible and fluorescence studies revealed that few of the compounds reported here exhibited emission of blue light upon irradiation in EtOH in the region of 404-422 nm.

Synthesis of α-keto-imides via oxidation of ynamides

(Chemical Equation Presented) A de novo preparation of α-keto-imides via ynamide oxidation is described. With a number of alkyne oxidation conditions screened, a highly efficient RuO2-NaIO4 mediated oxidation and a DMDO oxidation have been identified to tolerate a wide range of ynamide types. In addition to accessing a wide variety of α-keto-imides, the RuO2-NaIO4 protocol provides a novel entry to the vicinal tricarbonyl motif via oxidation of push-pull ynamides, and imido acylsilanes from silyl-substituted ynamides. Chemoselective oxidation of ynamides containing olefins can be achieved by using DMDO, while the RuO 2-NaIO4 protocol is not effective. These studies provide further support for the synthetic utility of ynamides.