128009-32-5 Usage
Description
5-(Trifluoromethyl)-2-thiophenecarboxylic acid is an organic compound characterized by the presence of a trifluoromethyl group at the 5th position and a carboxylic acid group at the 2nd position of the thiophene ring. It is a versatile building block in the synthesis of various pharmaceutical compounds and has potential applications in the development of new drugs.
Uses
Used in Pharmaceutical Industry:
5-(Trifluoromethyl)-2-thiophenecarboxylic acid is used as a reactant for the synthesis of substituted 1,2,3-triazoles, which are known as NR2B-selective NMDA modulators. These modulators play a crucial role in the treatment of various neurological disorders, such as chronic pain, anxiety, and depression, by targeting and modulating the activity of the NR2B subunit of the NMDA receptor.
Check Digit Verification of cas no
The CAS Registry Mumber 128009-32-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,0,0 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 128009-32:
(8*1)+(7*2)+(6*8)+(5*0)+(4*0)+(3*9)+(2*3)+(1*2)=105
105 % 10 = 5
So 128009-32-5 is a valid CAS Registry Number.
128009-32-5Relevant articles and documents
SYNTHESIS AND POLYMERISATION OF ETHYNYLTHIOPHENES AND ETHYNYLFURANS CONTAINING TRIFLUORMETHYL GROUPS
Nishida, Masakazu,Fujii, Shozo,Aoki, Toshiki,Hayakawa, Yoshio,Muramatsu, Hiroshige,Morita, Tomohiko
, p. 445 - 459 (2007/10/02)
Fluorination of thiophenedicarboxylic acid with sulfur tetrafluoride in the presence of anhydrous hydrogen fluoride provided mono and bis(trifluoromethyl)thiophenes in moderate yields.Ethynylthiophenes and ethynylfurans containing trifluoromethyl groups were prepared via 2,2-dichloro-1-fluorovinyl compounds.In polymerizations using transitions metal catalysts, 3-ethynylthiophenes gave polymers in high yields, which were soluble in THF and/or fluorocompounds, while 2-ethynylthiophenes polymerized in low yields.In γ-ray induced polymerization, only 2,5-bis(trifluoromethyl)-3-ethynylthiophene afforded the corresponding polymers.Thermal decomposition temperatures of polymers obtained increased by introduction of the trifluoromethyl groups as well as the methyl groups.