1280225-75-3

Basic information

• Product Name: C₂₀H₂₄N₂O₆
• Synonyms: C₂₀H₂₄N₂O₆
• CAS NO: 1280225-75-3
• Molecular Weight: 388.42
• Mol File: 1280225-75-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₄N₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₄N₂O₆(1280225-75-3)
• EPA Substance Registry System: C₂₀H₂₄N₂O₆(1280225-75-3)

Safety Data

• Hazardous Substances Data: 1280225-75-3(Hazardous Substances Data)

Upstream product

• 64744-41-8 N-hydroxy-3-azaspiro[5,5]undecane-2,4-dione 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 

Downstream Products

• 3005-87-6 Z-Gly-Gly-OEt 
• 1421-69-8 (S)-2-(2-Benzyloxycarbonylamino-acetylamino)-4-methyl-pentanoic acid 

Relevant articles and documents

3-Azaspiro[5,5]undecan-2,4-dioxo-3-yl diphenyl phosphate (ASUD-diphenyl phosphate), a new reagent for the synthesis of the N-protected amino acid-ASUD ester

A new reagent, 3-azaspiro[5,5]undecan-2,4-dioxo-3-yl diphenyl phosphate (ASUD-diphenyl phosphate) is described for the synthesis of N-protected amino acid-ASUD esters which are active esters useful in the synthesis of peptides. This compound was synthesized by reacting N-hydroxy-3-azaspiro[5,5]undecane-2,4-dione (HO-ASUD) with diphenyl chlorophosphate in the presence of a base at room temperature and was obtained in high yields. The ASUD-diphenyl phosphate reagent reacts with N-protected amino acids under mild conditions to give the corresponding ASUD active esters, while preserving the enantiomeric purity of the amino acid. The new reagent is a stable crystalline compound and eliminates the need for DCC, a potent skin allergen, used previously for the synthesis of N-protected amino acid-ASUD ester.