1280608-83-4Relevant articles and documents
Synthesis of isoxazoles en route to semi-aromatized polyketides: Dehydrogenation of benzonitrile oxide-para-quinone acetal cycloadducts
Hashimoto, Yoshimitsu,Takada, Akiomi,Takikawa, Hiroshi,Suzuki, Keisuke
scheme or table, p. 6003 - 6009 (2012/08/28)
A variety of highly functionalized polycyclic isoxazoles are prepared by a two-step protocol: (1) 1,3-dipolar cycloaddition of o,o′-disubstituted benzonitrile oxides to para-quinone mono-acetals, then (2) dehydrogenation. The cycloaddition proceeds in a regioselective manner, favouring the formation of the 4-acyl cycloadducts, which are suitable intermediates for the synthesis of semi-aromatized polycyclic targets derived from polyketide type-II biosynthesis.