128073-16-5

Basic information

• Product Name: 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER
• Synonyms: ETHYL 3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBOXYLATE;ETHYL 3-CHLORO-5-(TRIFLUOROMETHYL)PICOLINATE;2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER;3-Chloro-5-trifluoromethylpyridine-2-carboxylic acid ethyl ester;Ethyl 5-(trifluoroMethyl)-3-chloropyridine-2-carboxylate;3-Chloro-5-(trifluoroMethyl)2-pyridinecarboxylic acid ethyl ester;3-Chloro-2-(ethoxycarbonyl)-5-(trifluoromethyl)pyridine, Ethyl 3-chloro-5-(trifluoromethyl)picolinate;3- chloro -5- three fluoromethyl pyridine -2- formate
• CAS NO: 128073-16-5
• Molecular Formula: C9H7ClF3NO2
• Molecular Weight: 253.61
• Product Categories: Pyridines
• Mol File: 128073-16-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 64-66℃/0.008mm
• Flash Point: 121.2 °C
• Appearance: /
• Density: 1.389 g/cm³
• Vapor Pressure: 0.0047mmHg at 25°C
• Refractive Index: 1.4590 to 1.4630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.19±0.10(Predicted)
• CAS DataBase Reference: 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER(128073-16-5)
• EPA Substance Registry System: 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER(128073-16-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 128073-16-5(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarboxylic acid, 3-chloro-5-(trifluoromethyl)-, ethyl ester is a chemical compound that is commonly used as a synthetic intermediate in the production of agricultural chemicals and pharmaceuticals. It is a chloro-substituted derivative of the aromatic compound pyridinecarboxylic acid, and the ethyl ester group enhances its solubility and stability. The presence of the trifluoromethyl group also provides unique chemical reactivity and physical properties, making it suitable for a wide range of chemical applications. 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER is important in the development of new materials and drugs, and its synthesis and properties continue to be the subject of research and development in the chemical industry.

InChI:InChI=1/C9H7ClF3NO2/c1-2-16-8(15)7-6(10)3-5(4-14-7)9(11,12)13/h3-4H,2H2,1H3

Upstream product

• 80194-70-3 3-chloro-2-cyano-5-(trifluoromethyl)pyridine 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 69045-84-7 2,3-dichloro-5-trifluoromethylpyridine 

Downstream Products

• 1033463-30-7 3-chloro-5-(trifluoromethyl)picolinohydrazide 
• 1245784-27-3 ethyl 3-methanesulfonyl-5-trifluoromethylpyridine-2-carboxylate 
• 172527-65-0 1-(3-chloro-5-trifluoromethylpyridin-2-yl)-3-cyclopropylpropan-13-dione 
• 80194-68-9 3-chloro-5-trifluoromethylpyridine-2-carboxylic acid 

Relevant articles and documents

3 - chloro -5 - trifluoromethyl pyridine compounds and intermediates method (by machine translation)

The invention discloses a 3 - chloro -5 - trifluoromethyl pyridine compound and preparation method of the midbody. The invention of the formula 3 a compound represented by the preparation method, comprising the following steps: organic solvent and water in the mixed solvent, under the action of the phase transfer catalyst, shown as 2 shown with the metal cyanide compounds of the substitution reaction, carbonized 3 compound of formula; further comprises the following steps: in the solvent, under the effect of the fluorination reagent, shown as 1 shown in the fluorination reaction of the compound, prepared states like the type 2 compound of formula; and can also be further comprises the following steps: under the action of the hydrogen and ethanol, shown as 3 shown in the Pinner reaction compound, then hydrolyzing the ester reaction, carbonized 4 compounds are shown. The invention of 3 - chloro -5 - trifluoromethyl pyridine compound preparation method of low cost, high production safety, simple operation, high yield, it is suitable for industrial production. (by machine translation)

Synthetic process development and scale up of palladium-catalyzed alkoxycarbonylation of chloropyridines

2,3-Dichloropyridines undergo a mono- or a dicarbonylation in the presence of carbon monoxide, an alcohol, and a palladium catalyst, affording selectively either alkyl 3-chloropyridine-2-carboxylates or dialkyl pyridine-2,3-dicarboxylates in good yields, depending on the reaction conditions. For instance, the process could be scaled up for the monoalkoxycarbonylation of 2,3-dichloro-5-(trifluoromethyl)pyridine, affording in high yield and selectivity the corresponding 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate.

Pyrazole derivatives as herbicides

Compounds of the following formula I wherein wherein all variables are as defined in the specification and the pyrazoleN-oxides, agrochemically acceptable salts and stereisomers thereof useful as herbisdes.