1280738-14-8

Basic information

• Product Name: [1-(4-chlorophenyl)vinyloxy]triisopropylsilane
• Synonyms: [1-(4-chlorophenyl)vinyloxy]triisopropylsilane
• CAS NO: 1280738-14-8
• Molecular Weight: 310.939
• Mol File: 1280738-14-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: [1-(4-chlorophenyl)vinyloxy]triisopropylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(4-chlorophenyl)vinyloxy]triisopropylsilane(1280738-14-8)
• EPA Substance Registry System: [1-(4-chlorophenyl)vinyloxy]triisopropylsilane(1280738-14-8)

Safety Data

• Hazardous Substances Data: 1280738-14-8(Hazardous Substances Data)

Upstream product

• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 30780-45-1 1-(4-chlorophenyl)-2-methoxyethan-1-one 
• 121194-36-3 1-(4-chlorophenyl)-3,3,3-trifluoro-propan-1-one 

Relevant articles and documents

Synthesis of α-Difluoromethyl Aryl Ketones through a Photoredox Difluoromethylation of Enol Silanes

We report here an efficient and highly straightforward access to α-difluoromethylated ketones through a visible light-mediated difluoromethylation of readily available enol silanes. The method, which takes advantage of the polyvalence of Hu's reagent, N-tosyl-S-difluoromethyl-S-phenylsulfoximine, used here as a CHF2 radical precursor under catalytic photoredox conditions, is practical, scalable, and provides the corresponding α-CHF2 ketones in good to excellent yields.

Chemo- and Regioselective Ring Construction Driven by Visible-Light Photoredox Catalysis: an Access to Fluoroalkylated Oxazolidines Featuring an All-Substituted Carbon Stereocenter

The unique advantages conferred by incorporation of all-substituted carbon stereocenters in organic molecules have gained widespread recognition. In this work, we describe a three-component cyclization to access C-2 fluoroalkylated oxazolidines by fragments assembly of readily available silyl enol ether, fluoroalkyl halide, and chiral amino alcohol in a single reaction vessel, which provides an efficient strategy for expanding the pool of pharmaceutically important heterocycles featuring an all-substituted carbon stereocenter. This process proceeds efficiently in a chemo-, regio-, and stereoselective fashion under mild reaction conditions at room temperature and exhibits broad functional group tolerance. The successful realization of this controlled heteroannulation sequence relies on distinctive perfluoroalkylation, regio- and stereoselective radical cyclization through visible-light photoredox catalysis. Moreover, a one-pot procedure directly employing ketone as substrate has also been achieved. (Figure presented.).