128118-65-0

Basic information

• Product Name: 6-Chloro-5-phenyl-2-piperidin-1-yl-[1,3]oxazin-4-one
• CAS NO: 128118-65-0
• Molecular Weight: 290.749
• Mol File: 128118-65-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-Chloro-5-phenyl-2-piperidin-1-yl-[1,3]oxazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-5-phenyl-2-piperidin-1-yl-[1,3]oxazin-4-one(128118-65-0)
• EPA Substance Registry System: 6-Chloro-5-phenyl-2-piperidin-1-yl-[1,3]oxazin-4-one(128118-65-0)

Safety Data

• Hazardous Substances Data: 128118-65-0(Hazardous Substances Data)

Upstream product

• 17118-70-6 (chlorocarbonyl)phenyl ketene 
• 1530-87-6 1-piperidinylcarbonnitrile 

Relevant articles and documents

Synthese neuer 1,3-Oxazinone aus Cyanamiden und Chlorocarbonylketenen

Chlorocarbonylketenes 1a,b react with cyanamides 2a-i under mild conditions to form the 2-amino-1,3-oxazin-4-one derivatives 3a-i and 4 in mostly good yields.Treatment of compounds 3a,f with triethylamine in toluene in the presence of water or with triethylamine and benzylamine in toluene affords N-acylureas 5a,f, 2-amino-1,3-oxazin-4-ones 6, or malonamide 8, depending on the reaction conditions, whereas treatment of 3c with wet toluene leads to the formation of the 2-amino-1,3-oxazin-6-one 7.Cycloaddition of biscyanamides 9a-c and chlorocarbonylketene 1a leads to the bis-oxazinone derivatives 10a-c in low to moderate yields; in the case of 10a, the monosubstituted product 11a is obtained as a side product.