128300-28-7

Basic information

• Product Name: (R)-3-((R)-4-methylcyclohex-3-en-1-yl)butanal
• Synonyms: (R)-3-((R)-4-methylcyclohex-3-en-1-yl)butanal
• CAS NO: 128300-28-7
• Molecular Weight: 166.263
• Mol File: 128300-28-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-3-((R)-4-methylcyclohex-3-en-1-yl)butanal(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-((R)-4-methylcyclohex-3-en-1-yl)butanal(128300-28-7)
• EPA Substance Registry System: (R)-3-((R)-4-methylcyclohex-3-en-1-yl)butanal(128300-28-7)

Safety Data

• Hazardous Substances Data: 128300-28-7(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 5989-27-5 D-limonene 
• 64-17-5 ethanol 

Relevant articles and documents

Rhodium-catalyzed hydroformylation in γ-valerolactone as a biomass-derived solvent

Rhodium-catalyzed hydroformylation of styrene, α-methylstyrene, dimethyl itaconate, and (R)-limonene was performed in gamma-valerolactone (GVL) as a proposed biomass-based environmentally benign solvent for hydroformylation referring to toluene as a generally used conventional solvent. Both achiral (triphenylphosphine, 1,3-bis(diphenylphoshino)propane) and enantiopure bidentate phosphine ligands ((S,S)-BDPP, (R)-BINAP, (R)-QUINAP, (R,R)-DIOP, (Rc),(Sp)-JOSIPHOS, (S)-SEGPHOS, (S)-(DM)-SEGPHOS) were investigated in in situ generated Rh-diphosphine catalyst systems. In general, the catalysts' activity in GVL was lower than in toluene; however, remarkable chemo- (>99%) and regioselectivities (>95%) were achieved in GVL under identical conditions. The BDPP-modified Rh-catalyst was recycled for three consecutive cycles; however a decrease in its activity was detected.

Design and application of hybrid phosphorus ligands for enantioselective Rh-Catalyzed anti-markovnikov hydroformylation of unfunctionalized 1,1-disubstituted Alkenes

A series of novel hybrid phosphorus ligands were designed and applied to the Rh-catalyzed enantioselective anti-Markovnikov hydroformylation of unfunctionalized 1,1-disubstituted alkenes. By employing the new catalyst, linear aldehydes with β-chirality can be prepared with high yields and enantioselectivities under mild conditions. Furthermore, catalyst loading as low as 0.05 mol % furnished the desired product in good yield and undiminished selectivity, demonstrating the efficiency of this transformation in large-scale synthesis.