128311-06-8

Basic information

• Product Name: [R-(R*,S*)]-(-)-N-(1-PHENYLETHYL)-1-AZABICYCLO[2.2.2]OCTAN-3-AMINE DIHYDROCHLORIDE
• Synonyms: [R-(R*,S*)]-(-)-N-(1-PHENYLETHYL)-1-AZABICYCLO[2.2.2]OCTAN-3-AMINE DIHYDROCHLORIDE;(R-(R*,S*))-(-)-N-(1-phenylethyl)-1-aza-bicyclo(2;(-)-N-(1(R)-Phenylethyl)-1-azabicyclo[2.2.2]octan-3(S)-amine dihydrochloride, 98%;(3S)-N-[(1R)-1-Phenylethyl]-1-azabicyclo[2.2.2]octan-3-aMine Dihydrochloride
• CAS NO: 128311-06-8
• Molecular Formula: C₁₅H₂₂N₂*2ClH
• Molecular Weight: 303.27
• Product Categories: Chiral Building Blocks;Heterocyclic Building Blocks;Others;Amines;Heterocycles;Intermediates;Isotope Labelled Compounds
• Mol File: 128311-06-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 285 °C (dec.)(lit.)
• Boiling Point: 394.4°C at 760 mmHg
• Flash Point: 192.3°C
• Appearance: /
• Vapor Pressure: 1.32E-06mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: [R-(R*,S*)]-(-)-N-(1-PHENYLETHYL)-1-AZABICYCLO[2.2.2]OCTAN-3-AMINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: [R-(R*,S*)]-(-)-N-(1-PHENYLETHYL)-1-AZABICYCLO[2.2.2]OCTAN-3-AMINE DIHYDROCHLORIDE(128311-06-8)
• EPA Substance Registry System: [R-(R*,S*)]-(-)-N-(1-PHENYLETHYL)-1-AZABICYCLO[2.2.2]OCTAN-3-AMINE DIHYDROCHLORIDE(128311-06-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 128311-06-8(Hazardous Substances Data)

Usage

Uses

Palonsetron intermediate.

InChI:InChI=1/C15H22N2.2ClH/c1-12(13-5-3-2-4-6-13)16-15-11-17-9-7-14(15)8-10-17;;/h2-6,12,14-16H,7-11H2,1H3;2*1H/t12-,15-;;/m1../s1

Upstream product

• 1193-65-3 3-quinuclidinone hydrochloride 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 120570-06-1 N-((S)-1-phenylethyl)-3-quinuclidinimine 
• 120570-06-1 N-((R)-1-phenylethyl)-3-quinuclidinimine 

Downstream Products

• 142999-61-9 (S)-N-(R)-1-Aza-bicyclo[2.2.2]oct-3-yl-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 142999-61-9 (S)-N-(S)-1-Aza-bicyclo[2.2.2]oct-3-yl-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 142999-66-4 (1-chloromethyl)-(3R)-3-<(S)-(1-phenyl)ethylamino>quinuclidinium chloride 
• 6530-09-2 (3R)-quinuclidin-3-amine dihydrochloride 
• 6530-09-2 (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride 

Relevant articles and documents

Improved preparation of (R) and (S)-3-aminoquinuclidine dihydrochloride

An improved procedure for the synthesis of either (R) or (S)-3-aminoquinuclidine was developed. Key intermediate imine 2 was made in a one pot process using lithium oxide as the base and molecular sieves.

Enantiomers of absolute configuration S of amide derivatives of 3-aminoquinuclidine, the process for preparing them and their application in therapy

Enantiomer of absolute configuration S of formula: STR1 where: X=O or S; and Ar denotes a: * phenyl ring substituted with one, two or three C1 -C4 alkoxy groups; * phenyl ring substituted at the 2-position with a OCH3 group and at the 5-position with a halogen atom or a lower alkylcarbonyl group; * phenyl ring substituted at the 2-position with OCH3, at the 4-position with NH2 or alkylcarbonyl-NH and at the 5-position with a halogen; * 3-fluoro-2-methoxyphenyl group; * 5-pyrimidinyl group substituted at the 2-position with NH2 and in the 4-position with alkoxy or phenyloxy. These compounds are useful as medicinal products having activity in respect of gastric movements and antiemetic activity.