1283119-60-7

Basic information

• Product Name: tert-butyl 4-(5-benzylpyrimidin-2-yl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(5-benzylpyrimidin-2-yl)piperazine-1-carboxylate
• CAS NO: 1283119-60-7
• Molecular Weight: 354.452
• Mol File: 1283119-60-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 121-123 °C
• Boiling Point: 511.2±60.0 °C(Predicted)
• Density: 1.159±0.06 g/cm3(Predicted)
• CAS DataBase Reference: tert-butyl 4-(5-benzylpyrimidin-2-yl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(5-benzylpyrimidin-2-yl)piperazine-1-carboxylate(1283119-60-7)
• EPA Substance Registry System: tert-butyl 4-(5-benzylpyrimidin-2-yl)piperazine-1-carboxylate(1283119-60-7)

Safety Data

• Hazardous Substances Data: 1283119-60-7(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 374930-88-8 tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate 
• 62673-31-8 benzyl(bromo)zinc 
• 53317-09-2 9-benzyl-9-borabicyclo[3.3.1]nonane 

Downstream Products

• 1283119-34-5 5-benzyl-2-(4-benzylpiperazin-1-yl)pyrimidine 
• 1283119-36-7 5-benzyl-2-(4-(2-bromobenzyl)piperazin-1-yl)pyrimidine 
• 1283119-37-8 5-benzyl-2-(4-(2-bromo-5-fluorobenzyl)piperazin-1-yl)pyrimidine 
• 1283119-39-0 5-benzyl-2-(4-(3-hydroxybenzyl)piperazin-1-yl)pyrimidine 
• 1283119-41-4 5-benzyl-2-(4-(2-bromo-5-hydroxybenzyl)piperazin-1-yl)pyrimidine 
• 1283119-43-6 5-benzyl-2-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine 
• 1283119-45-8 5-benzyl-2-(4-(2-chloro-5-nitrobenzyl)piperazin-1-yl)pyrimidine 
• 1283119-47-0 2-(4-(2-(1H-pyrazol-4-yl)benzyl)piperazin-1-yl)-5-benzylpyrimidine 
• 1283119-49-2 5-benzyl-2-(4-(5-fluoro-2-(1H-pyrazol-4-yl)benzyl)piperazin-1-yl)pyrimidine 
• 1283119-55-0 2-(4-(3-aminobenzyl)piperazin-1-yl)-5-benzylpyrimidine 
• 1283119-57-2 5-benzyl-2-(4-(2-chloro-5-aminobenzyl)piperazin-1-yl)pyrimidine 
• 1283119-10-7 5-benzyl-2-(piperazin-1-yl)pyrimidine 
• 1310685-48-3 D-750776 
• 1310685-56-3 (4-(5-benzylpyrimidin-2-yl)piperazin-1-yl)(4-((2-phenylquinazolin-4-ylamino)methyl)phenyl)methanone 

Relevant articles and documents

COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT

Compounds and compositions useful for treating disorders related to KIT and PDFGR are described herein.

Anti-tumor pyrimidinylpiperazines bind to the prosurvival Bcl-2 protein family member Bcl-XL

Overexpression of prosurvival or underexpression of pro-death Bcl-2 family proteins can lead to cancer cell resistance to chemotherapy and radiation treatment. Inhibition of the prosurvival Bcl-2 family proteins has become a strategy for cancer therapy and inhibitors are currently being evaluated in the clinic both as single agents and in combination with established drugs. Here we describe the design, synthesis, and evaluation of pyrimidylpiperazines that were discovered to be inhibitors of the prosurvival Bcl-2 protein family member Bcl-XL. This study identified compound 21 which demonstrated a GI50 value of 8.4 μM against A549 lung adenocarcinoma cells and a binding affinity Ki value for Bcl-XL of 127 nM.