128372-97-4

Basic information

• Product Name: Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester
• CAS NO: 128372-97-4
• Molecular Formula: C12H23NO4
• Molecular Weight: 245.319
• Mol File: 128372-97-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester(128372-97-4)
• EPA Substance Registry System: Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester(128372-97-4)

Safety Data

• Hazardous Substances Data: 128372-97-4(Hazardous Substances Data)

Upstream product

• 6404-29-1 6-(tert-butoxycarbonylamino)hexanoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 27219-07-4 5-(N-tert-butyloxycarbonyl)aminopentanoic acid 
• 80860-42-0 tert-butyl 6-oxohexylcarbamate 
• 178172-34-4 tert-butyl 2-hydroxyazepane-1-carboxylate 
• 1309251-02-2 (3S,4S)-4-((3S,4S)-4-((3S,4S)-4-(ε-(N-isovalerylamino)hexanoyl)amino-3-hydroxy-6-methylheptanoylamino)-5-cyclohexyl-3-hydroxypentanoylamino)-3-hydroxy-6-methylheptanoic acid N-isoamylamide 
• 1309434-05-6 (3S,4S)-4-((3S,4S)-4-((3S,4S)-4-(ε-(N-isovalerylamino)hexanoyl)amino-3-hydroxy-6-methylheptanoylamino)-5-cyclohexyl-3-hydroxypentanoylamino)-3-hydroxy-6-methylheptanoic acid ethyl ester 
• 138199-80-1 Z-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OMe 
• 138199-81-2 Z-iPrTyr-D-Met-Gly-Phe-εAhx-εAhx-OMe 
• 138199-84-5 Z-PrTyr-D-Met-Gly-Phe-εAhx-OMe 
• 138199-85-6 Z-iPrTyr-D-Met-Gly-Phe-εAhx-OMe 
• 138199-83-4 H-iPrTyr-D-Met-Gly-Phe-εAhx-εAhx-OH 
• 138199-82-3 H-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OH 
• 138199-87-8 H-iPrTyr-D-Met-Gly-Phe-εAhx-OH 
• 138199-86-7 H-PrTyr-D-Met-Gly-Phe-εAhx-OH 
• 138199-75-4 Boc-Gly-Phe-εAhx-εAhx-OMe 

Relevant articles and documents

New renin inhibitors containing aliphatic or aromatic amides at the C-terminus

Five renin inhibitors, Iva-Pro-Phe(4-OMe)-MeLeu-Sta-εAhx-IAA (18), Iva-εAhx-Phe(4-OMe)-MeLeu-Sta-εAhx-IAA (23), H-εAhx-Phe(4-OMe)-His-Sta-εAhx-FBZA (36), H-εAhx-Phe(4-OMe)-His-Sta-εAhx-MBZA (45), and H-Phe (4-OMe)-His-Sta-εAhx-FBZA (48) have been synthesized in search of structures of improved biological properties. All synthesized inhibitors were resistant to chymotrypsin activity. Inhibitors 18 and 23 were insoluble in buffers, pH 7.4 and 2.0, 36, 45 and 48 were very good soluble in buffer pH 2.0 and poorly in buffer pH 7.4. Experimentally determined 1-octanol/pH 7.4 buffer partition coefficients (log P) of 36, 45 and 48 were above 1. Log P values of 18, 23, 36, 45 and 48 were 6.57, 6.91, 2.48, 2.09 and 2.00 respectively. The inhibitory potency in vitro of 18, 23, 36, 45 and 48 expressed as IC50 was 7.5 · 10-5, 5.0 · 10-6, 7.5 · 10-3, 1.0 · 10-4 and 2.5 · 10-5 M/l respectively.

SYNTHESIS OF ENKEPHALIN ANALOGS. PART IV. N-ALKYLATED DERIVATIVES

Four new derivatives of enkephalin analogs: H-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OH (24).H-iPrTyr-D-Met-Gly-Phe-εAhx-εAhx-Oh (25).H-Pr-Tyr-D-Met-Gly-Phe-εAhx-OH (30) and H-iPrTyr-D-Met-Gly-Phe-εAhx-OH (31) have been synthesized and tested for agonistic, antagonistic and analgesic activity.Compound 24 showed a moderate μ agonistic potency and high selectivity.