128438-01-7

Basic information

• Product Name: (Z)-2-(2-Aminothiazole-4-yl-)-2-trityloxyimino acetic acid
• Synonyms: (Z)-2-(2-AMINOTHIAZOLE-4-YL)-2-TRITYLOXYIMINO ACETIC ACID;(Z)-2-(2-AMINOTHIAZOL-4-YL)-2-(TRITYLOXY)IMINOACETIC ACID;ATOA;(Z)-2-(2-aminothiazol-4-yl)-2-trityliminoacetic acid;ATTAA:(Z)-2-(2-AMINOTHIAZOL-4-YL)-2-TRITYLOXYIMINOACETIC ACID;AT-TOA;( Z )-2-(2-AMINOTHIAZOL-4-YL)-2-TRITYLOXYIMINOACETIC ACID (ATOA);( Z )-2-(2-aminothiazol-4-yl)-2-trityloxyiminoacetic Acid (AT-TOA)
• CAS NO: 128438-01-7
• Molecular Formula: C₂₄H₁₉N₃O₃S
• Molecular Weight: 429.49
• Mol File: 128438-01-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 179-182 °C
• Boiling Point: 651.477 °C at 760 mmHg
• Flash Point: 347.801 °C
• Appearance: /
• Density: 1.295 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.66
• PKA: 2.66±0.10(Predicted)
• CAS DataBase Reference: (Z)-2-(2-Aminothiazole-4-yl-)-2-trityloxyimino acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(2-Aminothiazole-4-yl-)-2-trityloxyimino acetic acid(128438-01-7)
• EPA Substance Registry System: (Z)-2-(2-Aminothiazole-4-yl-)-2-trityloxyimino acetic acid(128438-01-7)

Safety Data

• Hazardous Substances Data: 128438-01-7(Hazardous Substances Data)

Usage

General Description

"(Z)-2-(2-Aminothiazole-4-yl-)-2-trityloxyimino acetic acid is a chemical compound that belongs to the class of organic compounds known as trityl-amino acids and derivatives. Its systematic name is (Z)-2-(2-Aminothiazole-4-yl)-2-(triphenylmethoxy)iminoacetic acid. It is potentially used in the field of biochemistry, particularly in pharmaceutical research for its possible biological activities. It consists of a trityl group, an aminothiazole ring, and an acetic acid group connected by an oxyimino linker. Its chemical properties and structure play important roles in its potential functions and applications. However, detailed information about its functions, uses, and safety profiles might be limited therefore further studies are needed.

InChI:InChI=1/C24H19N3O3S/c25-23-26-20(16-31-23)21(22(28)29)27-30-24(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-16H,(H2,25,26)(H,28,29)/b27-21-

Upstream product

• 76-83-5 trityl chloride 
• 64485-82-1 (Z)-ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate 
• 128438-00-6 ethyl (2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetate 
• 76-84-6 triphenylmethyl alcohol 

Downstream Products

• 163009-35-6 7β-acylcephem 
• 288379-92-0 diphenylmethyl 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(Z)-2-(3-pyridyl)vinylthio]-3-cephem-4-carboxylate 
• 288379-65-7 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(E)-2-(3-pyridyl)thiovinyl]-3-cephem-4-carboxylic acid 
• 288380-03-0 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(E)-2-(4-pyridyl)thiovinyl]-3-cephem-4-carboxylic acid 
• 200814-98-8 (Z)-(2-aminothiazol-4-yl)triphenylmethyloxyimino acetic acid diethoxythiophosphoryl ester 
• 163009-37-8 diphenylmethyl 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 220779-81-7 (6R,7R)-3-[(Z)-2-(3-Methoxy-isoxazol-5-yl)-vinyl]-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 220779-91-9 (6R,7R)-3-[(Z)-2-(3-Chloro-isoxazol-5-yl)-vinyl]-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 220779-47-5 (6R,7R)-3-((Z)-2-Isoxazol-5-yl-vinyl)-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 134482-51-2 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-chloromethyl-3-cephem-4-carboxylate 
• 288379-94-2 diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(3-pyridyl)thiomethylthio]-3-cephem-4-carboxylate 
• 163009-34-5 diphenylmethyl 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[2-(4-pyridyl)ethylthio]-3-cephem-4-carboxylate 
• 288380-05-2 diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate 

Relevant articles and documents

PROCESS FOR PREPARING 2-AMINOTHIAZOL-4-YL-ACETIC ACID DERIVATES

The invention provides a process for preparing a (2-aminothiazol-4-yl)-triarylmethyloxy- iminoacetic acid of the formula (I) or an ester thereof of the formula (II) wherein R1, R2 and R3 independently are optionally substi

Process for the preparation of cephem prodrug esters

The invention relates to a process for the preparation of cephem prodrug esters of the formula: STR1 in which R1 is C1 -C5 -alkanoyloxy-C1 -C3 -alkyl or C1 -C5 -alkoxycarbonyloxy

Process for cephem prodrug esters

A process for the selective formation of oximino o-protected derivatives of lower alkyl 2-(2-aminothiazol-4-yl)-2-oximinoacetates, and their use in the acylation of 7-amino-cephalosporin compounds is disclosed.