1285513-89-4 Usage
General Description
2-(benzyloxy)-5-bromo-N-(oxazol-2-yl)benzamide is a chemical compound with the molecular formula C20H15BrN2O3. It is a benzamide derivative containing a benzyl ether and a bromine substituent on the benzene ring, as well as an oxazole ring. 2-(benzyloxy)-5-bromo-N-(oxazol-2-yl)benzamide may have potential applications in medicinal chemistry and drug development due to its structural features that make it suitable for interaction with biological targets. Further research is warranted to explore its pharmacological properties and potential therapeutic uses.
Check Digit Verification of cas no
The CAS Registry Mumber 1285513-89-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,5,5,1 and 3 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1285513-89:
(9*1)+(8*2)+(7*8)+(6*5)+(5*5)+(4*1)+(3*3)+(2*8)+(1*9)=174
174 % 10 = 4
So 1285513-89-4 is a valid CAS Registry Number.
1285513-89-4Relevant articles and documents
Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors
Ding, Xiao,Dai, Xuedong,Long, Kai,Peng, Cheng,Andreotti, Daniele,Bamborough, Paul,Eatherton, Andrew J.,Edge, Colin,Jandu, Karamjit S.,Nichols, Paula L.,Philps, Oliver J.,Stasi, Luigi Piero,Wan, Zehong,Xiang, Jia-Ning,Dong, Kelly,Dossang, Pamela,Ho, Ming-Hsun,Li, Yi,Mensah, Lucy,Guan, Xiaoming,Reith, Alastair D.,Ren, Feng
, p. 4034 - 4038 (2017/08/23)
Leucine-rich repeat kinase 2 (LRRK2) has been suggested as a potential therapeutic target for Parkinson's disease. Herein we report the discovery of 5-substituent-N-arylbenzamide derivatives as novel LRRK2 inhibitors. Extensive SAR study led to the discovery of compounds 8e, which demonstrated potent LRRK2 inhibition activity, high selectivity across the kinome, good brain exposure, and high oral bioavailability.
