1285539-00-5Relevant articles and documents
Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors
Isaacs, Richard C.A.,Newton, Christina L.,Cutrona, Kellie J.,Mercer, Swati P.,Payne, Linda S.,Stauffer, Kenneth J.,Williams, Peter D.,Cook, Jacquelynn J.,Krueger, Julie A.,Lewis, S. Dale,Lucas, Bobby J.,Lyle, Elizabeth A.,Lynch, Joseph J.,McMasters, Daniel R.,Naylor-Olsen, Adel M.,Michener, Maria T.,Wallace, Audrey A.
, p. 1536 - 1540 (2011/04/23)
A novel 1,3,5-trisubstituted benzamide thrombin inhibitor template was designed via hybridization of a known aminopyridinoneacetamide and a known 1,3,5-trisubstituted phenyl ether. Optimization of this lead afforded a novel potent series of biaryl 1,3,5-trisubstituted benzenes with excellent functional anticoagulant potency.
