128626-47-1

Basic information

• Product Name: Benzoic acid, 3,3'-methylenebis[5-chloro-6-hydroxy-
• CAS NO: 128626-47-1
• Molecular Formula: C15H10Cl2O6
• Molecular Weight: 357.147
• Mol File: 128626-47-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3,3'-methylenebis[5-chloro-6-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3,3'-methylenebis[5-chloro-6-hydroxy-(128626-47-1)
• EPA Substance Registry System: Benzoic acid, 3,3'-methylenebis[5-chloro-6-hydroxy-(128626-47-1)

Safety Data

• Hazardous Substances Data: 128626-47-1(Hazardous Substances Data)

Upstream product

• 397843-09-3 3,3'-dicarbomethoxy-5,5'-dichloro-4,4'-dihydroxydiphenylmethane 
• 52159-67-8 methyl 3-chloro-2-hydroxybenzoate 
• 50-00-0 formaldehyd 
• 1829-32-9 3-Chloro-2-hydroxybenzoic acid 

Downstream Products

• 122-25-8 5,5'-methylenedisalicylic acid 
• 397843-09-3 3,3'-dicarbomethoxy-5,5'-dichloro-4,4'-dihydroxydiphenylmethane 
• 154023-64-0 3,3'-dicarbomethoxy-5,5'-dichloro-4,4'-dimethoxydiphenylmethane 
• 128626-48-2 3,3',3''-trimethoxycarbonyl-4,4',4''-trihydroxytriphenylcarbinol 
• 639-56-5 3,3',3''-tricarboxy-4,4',4''-trihydroxytriphenylcarbinol 
• 183487-85-6 tetra(3-chloro-4-methoxy-5-methoxycarbonylphenyl)ethylene 
• 154023-65-1 3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone 
• 397843-12-8 24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane 
• 397843-11-7 di[4-acetoxy-3-chloro-5-(methoxycarbonyl)phenyl]ketone 
• 397843-10-6 4,4'-diacetoxy-3,3'-dicarbomethoxy-5,5'-dichlorodiphenylmethane 
• 173173-55-2 3',3-dichloro-4',4-dihydroxy-5',5-bis(hydroxymethyl)-1,1-diphenylmethane 

Relevant articles and documents

Methylenedisalicylic acid derivatives: New PTP1B inhibitors that confer resistance to diet-induced obesity

Methylenedisalicylic acid derivatives were synthesized and their inhibitory activities against protein tyrosine phosphatases (PTPases) examined. Two of the compounds, 8 and 9, showed Ki values of 9.4 and 6.3 μM against PTP1B, 4- and 7-fold lower values compared to those against TC-PTP. They were reversible and slow-binding inhibitors against PTP1B. When compound 8 was fed to a mouse model, the weight gain and adipocyte fat storage induced by a high-fat-diet were significantly suppressed.

Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex

This patent pertains to selective inhibition of assembly of the membrane attack complex of complement by use of less than 1 kDa molecular weight forms of the aurin tricarboxylic acid synthetic complex (ATAC), and their derivatives. It further pertains to the use of these materials to treat human conditions where there is evidence of self destruction of host tissue by the membrane attack complex. These diseases include, but are not limited to, Alzheimer disease, age related macular degeneration, and atherosclerosis.

HETEROBIFUNCTIONAL COMPOUNDS FOR SELECTIN INHIBITION

Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise glycomimetics linked to a compound, for example a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).