128726-47-6

Basic information

• Product Name: (6S)-6-(HYDROXYMETHYL)-2-PIPERIDINONE
• Synonyms: (6S)-6-(HYDROXYMETHYL)-2-PIPERIDINONE;(+)-6-(Hydroxymethyl)-2-piperidinone;(S)-6-(Hydroxymethyl)piperidin-2-one;2-Piperidinone, 6-(hydroxymethyl)-, (6S)-
• CAS NO: 128726-47-6
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.15704
• EINECS: -0
• Mol File: 128726-47-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 346℃
• Flash Point: 163℃
• Appearance: /
• Density: 1.098
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.469
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 14.42±0.10(Predicted)
• CAS DataBase Reference: (6S)-6-(HYDROXYMETHYL)-2-PIPERIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: (6S)-6-(HYDROXYMETHYL)-2-PIPERIDINONE(128726-47-6)
• EPA Substance Registry System: (6S)-6-(HYDROXYMETHYL)-2-PIPERIDINONE(128726-47-6)

Safety Data

• Hazardous Substances Data: 128726-47-6(Hazardous Substances Data)

Usage

General Description

(6S)-6-(Hydromethyl)-2-piperidinone, also known as 6-hydroxymethyl-6,7,8,9-tetrahydropyrimidin-2(1H)-one or 6-hydroxymethyl-6,7,8,9-tetrahydropyrimidin-2-ol, is a chemical compound with the molecular formula C6H11NO2. It is a white solid with a piperidinone core structure and a hydroxymethyl group attached to the 6th position. (6S)-6-(HYDROXYMETHYL)-2-PIPERIDINONE is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its versatile nature and ability to participate in a range of chemical reactions make it a valuable intermediate in the production of various compounds. Additionally, it has potential applications in the field of medicinal chemistry for the development of new drugs. Overall, (6S)-6-(Hydromethyl)-2-piperidinone is a significant chemical building block with wide-ranging potential in the field of organic synthesis and drug discovery.

InChI:InChI=1/C6H11NO2/c8-4-5-2-1-3-6(9)7-5/h5,8H,1-4H2,(H,7,9)

Upstream product

• 209257-75-0 (S)-6-((tert-butyldiphenylsilyloxy)methyl)piperidin-2-one 
• 73538-21-3 (S)-2-(N-carbobenzoxy)amino-5-cyanopentanoic acid 
• 87174-86-5 (S)-(+)-α-aminoadipoic acid diethyl ester hydrochloride salt 
• 1118-90-7 L-homoglutamic acid 
• 213533-01-8 (S)-5-Azido-6-(tert-butyl-diphenyl-silanyloxy)-hexanoic acid 4-methoxy-benzyl ester 
• 187851-97-4 (4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate 
• 187851-96-3 (4-methoxyphenyl)methyl (R)-5,6-dihydroxyhexanoate 
• 187851-95-2 (4-methoxyphenyl)methyl hex-5-enoate 
• 2483-48-9 (+)-(S)-N₂,N₆-bis[(1,1-dimethylethoxy)carbonyl]-lysine methyl ester 
• 97347-42-7 (+)-(S)-N₂,N₆-bis[(1,1-dimethylethoxy)carbonyl]-6-oxo-lysine methyl ester 
• 158414-69-8 (-)-(S)-6-oxo-2-piperidinecarboxylic acid methyl ester 
• 128726-48-7 (S)-(-)-2-(N-carbobenzoxy)amino-5-hydroxypentanonitrile 
• 128726-44-3 (S)-6-oxo-piperidine-2-carboxylic acid ethyl ester 
• 34622-39-4 (2S)-6-oxopipecolic acid 

Downstream Products

• 135697-45-9 4-tert-Butyl-benzoic acid 2-({(S)-5-{(S)-5-tert-butoxycarbonylamino-6-[4-(4-tert-butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-hexanoylamino}-6-[4-(4-tert-butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-hexanoyl}-methyl-amino)-ethyl ester 
• 135697-41-5 {(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(S)-1-[4-(4-tert-butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-(piperidin-1-ylcarbamoyl)-butylcarbamoyl]-butyl}-carbamic acid tert-butyl ester 
• 135697-38-0 (S)-2-<<5-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxohexyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate 
• 135697-32-4 (S)-5-tert-Butoxycarbonylamino-6-[4-(4-tert-butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-hexanoic acid 4-nitro-phenyl ester 
• 135697-35-7 (S)-1,2-dimethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(1-piperidinylamino)pentyl>carbamate 
• 135697-37-9 {(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester 
• 135697-30-2 (S)-1,1-dimethylethyl 2-<<6-<<(1,1-dimethylethyl)benzoyl>amino>-9H-purin-9-yl>methyl>-1-piperidinecarboxylate 
• 135697-34-6 (S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(benzylamino)pentyl>carbamate 
• 135697-27-7 (S)-δ-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<<4-(1,1-dimethylethyl)benzoyl>amino>-2-oxo-1(2H)-pyrimidinehexanoic acid 
• 135697-23-3 (S)-1,1-dimethylethyl 2-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate 
• 135697-31-3 4-tert-Butyl-N-[9-((S)-6-oxo-piperidin-2-ylmethyl)-9H-purin-6-yl]-benzamide 
• 135697-17-5 (S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate 
• 135697-11-9 (S)-1,1-dimethylethyl 2-<<4-amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate 
• 135697-19-7 (S)-δ-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinehexanoic acid 

Relevant articles and documents

General synthesis of pyrroloquinolizidines: Synthesis of an unnatural homologue of the pyrroloindolizidine myrmicarin alkaloid 215B

A general synthesis approach to pyrroloquinolizidines (3,4,5,5a,6,7,8- heptahydropyrrolo[2,1,5-de]-quinolizines) via a muenchnone 1,3-dipolar cycloaddition is reported. The approach was applied to the synthesis of an unnatural pyrroloquinolizidine homologue of myrmicarin 215B.

Diels-Alder reactions of 6-substituted 1-(p-nitrobenzoyl)-5,6-dihydro-2-pyridinones

The first examples of Diels-Alder cycloaddition reactions of 6-substituted 1-(p-nitrobenzoyl)-5,6-dihydro-2-pyridinones are described. This reaction benefits from the fact that the diene adopts an endo orientation trans to the axial substituent at C-6 due to A1,3 allylic type strain with the N-PNB protecting group.

Convenient preparations of racemic and enantiopure methyl 6-oxopipecolate

Short, convenient syntheses of racemic and enantiopure methyl 6-oxopipecolate are described, starting from either pipecolic acid or (S)-lysine respectively. The sequence for the latter compound relies upon improved methodology for the oxidation of C-6 of