128812-11-3Relevant articles and documents
Et2Zn-mediated stoichiometric C(sp)-H silylation of 1-alkynes and chlorosilanes
Huang, Pan,Xu, Dawen,Reich, Robert M.,Kaiser, Felix,Liu, Boping,Kühn, Fritz E.
, p. 1574 - 1577 (2019/05/17)
A first example of an Et2Zn mediated silylation of 1-aklynes is reported. A series of functional groups are tolerated in this reaction. Mechanistic studies support Zn alkynilides as intermediates in the reaction. This reaction protocol provides a practical method for the preparation of alkynylsilanes and expands the application of organometallic zinc in organic synthesis.
A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes
Chen, Shan-Yong,Liu, Winnie,Wu, Xuedan,Ying, Jun,Yu, Xiaoqi,Pu, Lin
, p. 358 - 361 (2015/01/09)
An easily available BINOL-Ti(OiPr)4 catalyst system is found to activate the reaction of Zn powder with EtI for the asymmetric alkyne addition to aldehydes at room temperature. It allows the synthesis of a number of synthetically useful chiral propargylic alcohols with both high yields and high enantioselectivity (up to >96% ee). This journal is
