128923-28-4 Usage
Description
Org 5222 glucuronide, also known as N-Desmethyl Asenapine N-Carbamoyl Glucuronide, is a metabolite of Asenapine (A788000), which is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist. It is structurally related to Mianserin (M341500). Org 5222 glucuronide plays a significant role in the metabolism and elimination of Asenapine from the body.
Uses
Used in Pharmaceutical Industry:
Org 5222 glucuronide is used as a metabolite in the development and study of Asenapine for its pharmacological properties. It helps in understanding the drug's metabolism, efficacy, and safety profile.
Used in Research and Development:
Org 5222 glucuronide is used as a research tool for studying the metabolism and pharmacokinetics of Asenapine. It aids in the development of new drugs with improved pharmacological properties and reduced side effects.
Used in Drug Metabolism Studies:
Org 5222 glucuronide is used as a reference compound in drug metabolism studies, helping researchers to understand the metabolic pathways and enzyme interactions involved in the elimination of Asenapine from the body.
Used in Quality Control and Standardization:
Org 5222 glucuronide is used as a quality control and standardization agent in the pharmaceutical industry. It ensures the consistency, purity, and potency of Asenapine and its related compounds in various formulations.
Check Digit Verification of cas no
The CAS Registry Mumber 128923-28-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,9,2 and 3 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 128923-28:
(8*1)+(7*2)+(6*8)+(5*9)+(4*2)+(3*3)+(2*2)+(1*8)=144
144 % 10 = 4
So 128923-28-4 is a valid CAS Registry Number.
InChI:InChI=1/C23H22ClNO9/c24-10-5-6-16-12(7-10)14-9-25(8-13(14)11-3-1-2-4-15(11)32-16)23(31)34-22-19(28)17(26)18(27)20(33-22)21(29)30/h1-7,13-14,17-20,22,26-28H,8-9H2,(H,29,30)/t13?,14?,17-,18-,19+,20-,22-/m0/s1
128923-28-4Relevant articles and documents
Biotransformation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate in rats
d. Wildenberg,Delbressine,Kaspersen,Wagenaars,Jacobs
, p. 540 - 544 (2007/10/02)
The metabolism of trans-5-chloro-2-methyl-2,3,3a-12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate (Org 5222) labelled with [3H] or [14C] was investigated in Wistar rats. Metabolites were identified by mass spectrometry, 13C- and 1H-NMR analysis, IR spectroscopy and, wherever possible, by comparison with authentic reference compounds. The metabolites found in plasma, bile, faeces and urine revealed the processes of metabolism in which Org 5222 underwent oxidation to yield an N-oxide existing in two diastereoisomeric forms, or N-demethylation to yield a demethyl metabolite. A novel metabolite was found in bile viz. a carbamate glucuronide, formed from an intermediate carbamic acid, derived from the addition of CO2 to the demethyl metabolite.
